Anti-Laminin-332 Mucous Membrane Pemphigoid in a 9-Year Old Girl

被引：6
|
作者：
Kahn, Estelle [1 ]
Spence Shishido, Allyson [1 ]
Yancey, Kim B. [2 ]
Lawley, Leslie P. [1 ]
机构：
[1] Emory Univ Hosp, Dept Dermatol, Atlanta, GA 30322 USA
[2] Univ Texas SW Med Ctr Dallas, Dept Dermatol, Dallas, TX 75390 USA
来源：
PEDIATRIC DERMATOLOGY | 2014年 / 31卷 / 03期
关键词：
SUBEPIDERMAL BLISTERS; EPILIGRIN; LIGAND;
D O I：
10.1111/pde.12210
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Mucous membrane pemphigoid (MMP), an autoimmune subepithelial blistering disease that predominantly affects the mucous membranes, is usually diagnosed in elderly adults. Early diagnosis of MMP is crucial because it tends to run a chronic and progressive course with the potential for devastating scarring of the mucous membranes that may lead to blindness and airway compromise. A subtype of MMP, anti-laminin-332 MMP, is a rare blistering disorder in which autoantibodies are directed against laminin-332 (formerly epiligrin), a structural protein of the epidermal basement membrane. Herein we report what we believe to be the youngest patient diagnosed with anti-laminin-332 MMP, a 9-year-old girl with disease affecting only the oral, pharyngeal, and laryngeal mucosa, with no skin involvement.
引用
收藏
页码：E76 / E79
页数：4
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