Unnatural amino acid derived FRET cassettes, terminators and their DNA sequencing potential

被引：13

作者：

Nampalli, S

Zhang, WH

Rao, TS

Xiao, HG

Kotra, LP

Kumar, S

机构：

[1] Amersham Biosci, Piscataway, NJ 08855 USA

[2] Univ Toronto, Fac Pharm, Toronto, ON M5S 2S2, Canada

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 11期

关键词：

D O I：

10.1016/S0040-4039(02)00196-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unnatural, tri-functional amino acid. t-BOC-L-para-amino-phenylalanine (1). was utilized in the design and syntheses of highly efficient FRET cassettes (4-7) and converted them into 2'.3'-dideoxynucleotide terminators (8-11) for investigating DNA sequencing potential coupled with a thermostable DNA polymerase. Thermo Sequenase(TM) II . (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1999 / 2003

页数：5

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