Unnatural amino acid derived FRET cassettes, terminators and their DNA sequencing potential

被引：13
|
作者：
Nampalli, S
Zhang, WH
Rao, TS
Xiao, HG
Kotra, LP
Kumar, S
机构：
[1] Amersham Biosci, Piscataway, NJ 08855 USA
[2] Univ Toronto, Fac Pharm, Toronto, ON M5S 2S2, Canada
来源：
TETRAHEDRON LETTERS | 2002年 / 43卷 / 11期
关键词：
D O I：
10.1016/S0040-4039(02)00196-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An unnatural, tri-functional amino acid. t-BOC-L-para-amino-phenylalanine (1). was utilized in the design and syntheses of highly efficient FRET cassettes (4-7) and converted them into 2'.3'-dideoxynucleotide terminators (8-11) for investigating DNA sequencing potential coupled with a thermostable DNA polymerase. Thermo Sequenase(TM) II . (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1999 / 2003
页数：5
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