Technological Profile of Lipases in the Pharmaceutical Industry

被引:7
|
作者
Pinto, Gabrielle Barbosa [1 ]
Lins Mendes, Flavia Maria [1 ]
de Souza Antunes, Adelaide Maria [1 ,2 ]
机构
[1] Univ Fed Rio de Janeiro, Sch Chem, Rio De Janeiro, Brazil
[2] Natl Inst Ind Property, Rio De Janeiro, Brazil
关键词
Biochemistry; drugs; enzymatic catalysts; hydrolases; lipase; pharmaceutical industry; DYNAMIC KINETIC RESOLUTION; CATALYZED OPTICAL RESOLUTION; ENZYMATIC-SYNTHESIS; ACID-ESTERS; CHEMOENZYMATIC SYNTHESIS; EFFICIENT RESOLUTION; IMMOBILIZED LIPASES; MICROBIAL LIPASES; CARBOXYLIC-ACIDS; MANDELIC-ACID;
D O I
10.2174/1570193X16666190913181530
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
In recent decades, enzymes have been the target of considerable research, development, and innovation. This paper presents an up-to-date overview of the technological application of lipases in the pharmaceutical industry. Lipases have been used in a variety of ways in the pharmaceutical industry, both for obtaining bioactive molecules to overcome limitations in the formulation of medicines and in drug design. This is possible from alternative technologies, such as immobilization and the use of non-aqueous solvents that allow the use of lipases in commercial-scale processes. In addition, other technologies have provided the emergence of differentiated and more specific lipases in order to meet the perspectives of industrial processes. The research indicates that the following years should be promising for the application of lipase in the industrial biocatalysis and in drug design.
引用
收藏
页码:701 / 716
页数:16
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