Assessing Die Filling Using High-Speed Camera Imaging

被引:0
|
作者
Hildebrandt, Claudia [1 ]
Loerzer, Jost [2 ,3 ]
Gopireddy, Srikanth R. [3 ]
Urbanetz, Nora [3 ]
机构
[1] Univ Kiel, Dept Pharmaceut & Biopharmaceut, Grasweg 9a, D-24118 Kiel, Germany
[2] Tech Univ Clausthal, Adolph Roemer Str 2a, D-38678 Clausthal Zellerfeld, Germany
[3] Dauchi Sankyo Europe GmbH, Pharmaceut Dev, Luitpoldstr 1, D-85276 Pfaffenhofen, Germany
关键词
Die filling; High-speed camera imaging; Pharmaceutical tableting; Powder flow; Powder characterization; ROTARY TABLET PRESS; FLOW; POWDERS; DYNAMICS;
D O I
10.1002/cite.201700115
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
The study presents the die filling process of pharmaceutical powders using high-speed camera imaging. The objectives are to qualitatively visualize and to quantify the powder flow. A model die filling system with a shoe for powder storage and a moving die underneath the shoe was designed. The die filling process is captured through a high-speed camera and the images allow flow type identification and flow rate calculation. Correlations are generated to predict the fill ratios and flow rates based on particle size data, which could help in process understanding and optimization of die filling.
引用
收藏
页码:472 / 482
页数:11
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