De novo variants in gene regulatory regions contribute to CHD

被引：0
|
作者：
Fernandez-Ruiz, Irene
机构：
[1] Nature Reviews Cardiology,
来源：
NATURE REVIEWS CARDIOLOGY | 2020年 / 17卷 / 09期
关键词：
D O I：
10.1038/s41569-020-0420-x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Non-coding de novo variants (DNVs) contribute to congenital heart disease (CHD) through transcriptional and post-transcriptional regulatory effects during cardiac development. The proportion of individuals with CHD ascribed to non-coding DNVs might be at least as high as that with CHD attributed to coding DNVs
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页码：541 / 541
页数：1
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