Synthesis and Formylation of Substituted 2-Spiropyrimidin-4-ones and Related Compounds

被引：7

作者：

Markov, V. I. ^{[1
]}

Farat, O. K. ^{[1
]}

Varenichenko, S. A. ^{[1
]}

Velikaya, E. V. ^{[1
]}

Zubatyuk, R. I. ^{[2
]}

Shishkin, O. V. ^{[2
,3
]}

机构：

[1] Ukrainian State Univ Chem Technol, UA-49005 Dnepropetrovsk, Ukraine

[2] Natl Acad Sci Ukraine, State Sci Inst Inst Single Crystals, UA-61001 Kharkov, Ukraine

[3] Kharkov Natl Univ, UA-61077 Kharkov, Ukraine

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2013年 / 49卷 / 08期

关键词：

cyclohexanone-2-carboxamide; hydroacridine derivatives; rearrangement; Vilsmeier-Haack reagent; KETONES;

D O I：

10.1007/s10593-013-1358-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of cyclohexanone-2-carboxamide with cyclic ketones provides oxazine derivatives while refluxing in toluene with ammonium acetate and cyclic ketones yields substituted 2-spiropyrimidin-4-ones. Depending on the ratio of reactants, the oxazines and substituted 2-spiropyrimidin-4-ones under Vilsmeier-Haack conditions undergo formylation or an electrophilic rearrangement.

引用

页码：1158 / 1165

页数：8

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