Are Women with Severely Symptomatic Brugada Syndrome Different from Men?

被引:33
|
作者
Sacher, Frederic [1 ]
Meregalli, Paola [2 ]
Veltmann, Christian [3 ]
Field, Michael E. [1 ]
Solnon, Aude [4 ]
Bru, Paul [5 ]
Abbey, Selim [6 ]
Jais, Pierre [1 ]
Tan, Hanno L. [2 ]
Wolpert, Christian [3 ]
Lande, Gilles [6 ]
Bertault, Valerie [7 ]
Derval, Nicolas [1 ]
Babuty, Dominique [8 ]
Lacroix, Dominique [9 ]
Boveda, Serge [10 ]
Maury, Philippe [11 ]
Hocini, Meleze [1 ]
Clementy, Jacques [1 ]
Mabo, Philippe [4 ]
Lemarec, Herve [6 ]
Mansourati, Jacques [7 ]
Borggrefe, Martin [3 ]
Wilde, Arthur [2 ]
Haissaguerre, Michel [1 ]
Probst, Vincent [6 ]
机构
[1] Univ Bordeaux 2, CHU Bordeaux, F-33076 Bordeaux, France
[2] Univ Amsterdam, NL-1012 WX Amsterdam, Netherlands
[3] Univ Klinikum Mannheim, Mannheim, Germany
[4] CHU Rennes, Rennes, France
[5] CH La Rochelle, La Rochelle, France
[6] CHU Nantes, Nantes, France
[7] CHU Brest, Brest, France
[8] CHU Tours, Tours, France
[9] CHU Lille, Lille, France
[10] Clin Pasteur, Toulouse, France
[11] CHU Toulouse, Toulouse, France
关键词
Brugada syndrome; gender; sudden cardiac death; implantable defibrillator;
D O I
10.1111/j.1540-8167.2008.01223.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Women with Brugada Syndrome. Introduction: Spontaneous type-1 ECG has been recognized as a risk factor for sudden cardiac death (SCD) in Brugada syndrome (BrS), but studied populations predominantly consisted of men. We sought to investigate whether a spontaneous type-1 ECG pattern was also associated in women with severely symptomatic BrS. Other known risk factors were also examined for gender specificity. Methods: Patients with severely symptomatic BrS, defined as resuscitated SCD and/or appropriate implantable cardioverter-defibrillator (ICD) shock, were included from 11 European centers. Clinical data, investigation of family history, 12-lead ECG, and results of electrophysiological study (EPS) were collected. The average follow-up was 4 +/- 3 years. Results: Fifty-eight patients fulfilled the inclusion criteria (mean age 47 +/- 11 years, 8 women). Thirty-six men (72%) but only two women (25%) had a spontaneous type-1 ECG at baseline (P = 0.02). Maximal ST elevation before or after drug challenge was 3.7 +/- 1.3 mm in men versus 2.4 +/- 0.7 mm in women (P = 0.007). The proportion of patients with a family history of SCD or an SCN5A mutation was not significantly different between both groups. Of those patients with high-risk BrS who underwent EPS, 76%(12/25) of men and 50%(2/4) of women had a positive study. Conclusion: In contrast to men, most women with BrS and resuscitated SCD or appropriate ICD shock do not have a spontaneous type-1 ECG pattern. In addition, the degree of ST elevation is less pronounced in women than men. While women represent a lower-risk group overall, risk factors established from a predominantly male population may not be helpful in identifying high-risk females. (J Cardiovasc Electrophysiol, Vol. 19, pp. 1181-1185, November 2008).
引用
收藏
页码:1181 / 1185
页数:5
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