Autophagy, signaling and obesity

被引：59

作者：

Lavallard, Vanessa J. ^{[1
,2
]}

Meijer, Alfred J. ^{[4
]}

Codogno, Patrice ^{[5
]}

Gual, Philippe ^{[1
,2
,3
]}

机构：

[1] INSERM, U1065, Equipe Complicat Hepat Obesite 8, Batiment Univ ARCHIMED,151 Route St Antoine Gines, F-06204 Nice 03, France

[2] Univ Nice Sophia Antipolis, Fac Med, Nice, France

[3] Hop Archet, Ctr Hosp Univ Nice, Dept Digestif, Nice, France

[4] Univ Amsterdam, Acad Med Ctr, Dept Med Biochem, NL-1105 AZ Amsterdam, Netherlands

[5] Univ Paris 11, INSERM, U984, F-92296 Chatenay Malabry, France

来源：

PHARMACOLOGICAL RESEARCH | 2012年 / 66卷 / 06期

关键词：

Autophagy; Lipophagy; Liver; Adipose tissue; Pancreas; NAFLD; ENDOPLASMIC-RETICULUM STRESS; ACTIVATED PROTEIN-KINASE; TRANSFER-RNA SYNTHETASE; INDUCED CELL-DEATH; AMINO-ACID; OXIDATIVE STRESS; ER STRESS; INSULIN-RESISTANCE; BECLIN; MITOCHONDRIAL DYSFUNCTION;

D O I：

10.1016/j.phrs.2012.09.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Autophagy is a cellular pathway crucial for development, differentiation, survival and homeostasis. Autophagy can provide protection against aging and a number of pathologies such as cancer, neurodegeneration, cardiac disease and infection. Recent studies have reported new functions of autophagy in the regulation of cellular processes such as lipid metabolism and insulin sensitivity. Important links between the regulation of autophagy and obesity including food intake, adipose tissue development, beta cell function, insulin sensitivity and hepatic steatosis exist. This review will provide insight into the current understanding of autophagy, its regulation, and its role in the complications associated with obesity. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：513 / 525

页数：13

共 50 条

[21] Defects of Nutrient Signaling and Autophagy in Neurodegeneration
Ondaro, Jon
Hernandez-Eguiazu, Haizea
Garciandia-Arcelus, Maddi
Loera-Valencia, Raul
Rodriguez-Gomez, Laura
Jimenez-Zuniga, Andres
Goikolea, Julen
Rodriguez-Rodriguez, Patricia
Ruiz-Martinez, Javier
Moreno, Fermin
Lopez de Munain, Adolfo
Holt, Ian James
Gil-Bea, Francisco Javier
Gerenu, Gorka
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 10
[22] mTOR Signaling in Autophagy Regulation in the Kidney
Inoki, Ken
SEMINARS IN NEPHROLOGY, 2014, 34 (01) : 2 - 8
[23] Signaling alterations caused by drugs and autophagy
Dent, Paul
Booth, Laurence
Poklepovic, Andrew
Hancock, John F.
CELLULAR SIGNALLING, 2019, 64
[24] Inflammatory signaling cascades and autophagy in cancer
Monkkonen, Teresa
Debnath, Jayanta
AUTOPHAGY, 2018, 14 (02) : 190 - 198
[25] Insulin Signaling Suppresses Autophagy in Astrocytes
Geffken, Shawn
Smith, Catherine
Lee, Hiu H.
Cai, Weikang
FASEB JOURNAL, 2022, 36
[26] The pleiotropic roles of sphingolipid signaling in autophagy
Li, Y.
Li, S.
Qin, X.
Hou, W.
Dong, H.
Yao, L.
Xiong, L.
CELL DEATH & DISEASE, 2014, 5 : e1245 - e1245
[27] Crosstalk between Autophagy and RLR Signaling
Ke, Po-Yuan
CELLS, 2023, 12 (06)
[28] Regulation of Autophagy by mTOR Signaling Pathway
Wang, Ying
Zhang, Hongbing
AUTOPHAGY: BIOLOGY AND DISEASES: BASIC SCIENCE, 2019, 1206 : 67 - 83
[29] Autophagy and the Wnt signaling pathway: A focus on Wnt/β-catenin signaling
Lorzadeh, Shahrokh
Kohan, Leila
Ghavami, Saeid
Azarpira, Negar
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2021, 1868 (03):
[30] Understanding and exploiting autophagy signaling in plants
Batoko, Henri
Dagdas, Yasin
Baluska, Frantisek
Sirko, Agnieszka
SIGNALLING MECHANISMS IN AUTOPHAGY, 2017, 61 (06): : 675 - 685

← 1 2 3 4 5 →