A vaccine for human babesiosis: prospects and feasibility

被引：5

作者：

Al-Nazal, Hanan ^{[1
]}

Low, Leanne M. ^{[2
]}

Kumar, Sanjai ^{[3
]}

Good, Michael F. ^{[1
]}

Stanisic, Danielle I. ^{[1
]}

机构：

[1] Griffith Univ, Inst Glyc, Gold Coast Campus, Griffith, Qld, Australia

[2] Natl Inst Allergy & Infect Dis, NIH, Lab Malaria & Vector Res, Rockville, MD USA

[3] FDA, Ctr Biol Evaluat & Res, Div Emerging & Transfus Res & Review, Silver Spring, MD USA

来源：

TRENDS IN PARASITOLOGY | 2022年 / 38卷 / 10期

基金：

英国医学研究理事会;

关键词：

RHOPTRY NECK PROTEIN-2; MICROTI INFECTION; BOVINE BABESIOSIS; GAMMA-INTERFERON; PROTECTIVE IMMUNITY; MALARIA PARASITE; T-CELLS; ANTIGENS; CATTLE; CANIS;

D O I：

10.1016/j.pt.2022.07.005

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Babesiosis is a tick-borne disease caused by intraerythrocytic Babesia parasites. It is a well-known illness in companion animals and livestock, resulting in substan-tial economic losses in the cattle industry. Babesiosis is also recognized as an emerging zoonosis of humans in many countries worldwide. There is no vaccine against human babesiosis. Currently, preventive measures are focused on vector avoidance. Although not always effective, treatment includes antimicrobial therapy and exchange transfusion. In this review, we discuss the host's immune response to the parasite, vaccines being used to prevent babesiosis in animals, and lessons from malaria vaccine development efforts to inform the development of a human babesiosis vaccine. An effective human vaccine would be a significant advance towards curtailing this rapidly emerging disease.

引用

页码：904 / 918

页数：15

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