Myxobacterial epothilones and tubulysins as promising anticancer agents

被引：36

作者：

Doemling, Alexander ^{[1
]}

Richter, Wolfgang ^{[1
]}

机构：

[1] R&D Biopharmaceut, Munich, Germany

来源：

MOLECULAR DIVERSITY | 2005年 / 9卷 / 1-3期

关键词：

epothilone; tubulin binder; tubulysin;

D O I：

10.1007/s11030-005-1542-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tubulin-binding agents play a pivotal role in current cancer therapy and there are many efforts in pre-clinical and clinical development of known and novel cytotoxic agents ongoing. In this article a known class, epothilones, as well as a novel class, tubulysins, are presented.

引用

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页码：141 / 147

页数：7

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