Tranexamic Acid for Reduction of Blood Loss During Total Hip Arthroplasty

被引：125

作者：

Imai, Norio ^{[1
]}

Dohmae, Yoichiro ^{[1
]}

Suda, Ken ^{[2
]}

Miyasaka, Dai ^{[2
]}

Ito, Tomoyuki ^{[2
]}

Endo, Naoto ^{[2
]}

机构：

[1] Niigata Prefectural Shibata Hosp, Dept Orthopaed Surg, Shibata, Japan

[2] Niigata Univ, Dept Orthopaed Surg, Med & Dent Hosp, Niigata, Japan

来源：

JOURNAL OF ARTHROPLASTY | 2012年 / 27卷 / 10期

关键词：

tranexamic acid; total hip arthroplasty; blood loss; KNEE ARTHROPLASTY; SURGERY; REPLACEMENT; CONSERVATION; METAANALYSIS; OPERATIONS;

D O I：

10.1016/j.arth.2012.04.024

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

In this study, we evaluated the hemostatic effects of tranexamic acid (TNA), an antifibrinolytic drug, by examining the timing of its administration during total hip arthroplasty. One hundred seven patients being treated for osteoarthritis of the hip joint were randomly divided into 5 groups based on the timing of TNA administration. The intraoperative blood loss, postoperative blood loss, and hemoglobin of these patients who received TNA at different times during the procedure were monitored. We found that the intraoperative blood loss in the preoperative TNA administration groups was significantly lower than both control and postoperative TNA administration groups. Furthermore, 1 g TNA 10 minutes before surgery and 6 hours after the first administration was most effective for the reduction of blood loss during total hip arthroplasty.

引用

页码：1838 / 1843

页数：6

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