In Vitro Potency and In Vivo Efficacy of a Novel Bis-Indole Antimicrobial Compound in Reducing Catheter Colonization

被引：7
|
作者：
Mansouri, Mohammad D. [1 ,2 ]
Opperman, Timothy J. [3 ]
Williams, John D. [3 ]
Stager, Charles [1 ,2 ]
Darouiche, Rabih O. [1 ,2 ]
机构：
[1] Baylor Coll Med, Houston, TX 77030 USA
[2] Michael E DeBakey VA Med Ctr, Houston, TX USA
[3] Microbiotix Inc, Worcester, MA USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 04期
基金：
美国国家卫生研究院;
关键词：
STAPHYLOCOCCUS-AUREUS INFECTION; PREVENTION;
D O I：
10.1128/AAC.05521-11
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Vascular catheters coated with a novel antimicrobial agent (MBX1631) were studied for their ability to protect against bacterial colonization in vitro and in a rabbit model. MBX1631-coated catheters were significantly less likely to become colonized than control catheters both in vitro and in vivo (P < 0.001). Furthermore, device-associated infection was significantly lower in MBX1631-coated catheters than in uncoated ones (P < 0.005).
引用
收藏
页码：2201 / 2204
页数：4
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