Validation of warfarin pharmacogenetic algorithms in 586 Han Chinese patients

Aim: To compare the accuracy of the nine selected algorithms for predicting warfarin dose with 586 Han Chinese patients. Materials & methods: Genotyping of VKORC1 1639G>A, CYP2C9*2 and CYP2C9*3 variants was performed. Both the mean absolute error and ideal estimation value were used for comparison. Results: The top three performers were from East Asians. The algorithms from Caucasians generally performed better in the medium-dose subgroup (>3 and <7 mg/day), while the algorithms from East Asians generally performed better in the low-dose subgroup (<= 3 mg/day). None of the algorithms performed well in the high-dose subgroup (>= 7 mg/day). Conclusion: Algorithms built for specific ethnic groups and p-reassigned-dose groups are suggested for better prediction.