A new FRET-based ratiometric fluorescent probe for the detection of SO2 derivatives in mitochondria of living cells

被引：23
|
作者：
Wang, Wei [1 ]
Li, Na [2 ]
Liu, Jin-Ting [1 ]
Miao, Jun-Ying [2 ]
Zhao, Bao-Xiang [1 ]
Lin, Zhao-Min [3 ]
机构：
[1] Shandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Peoples R China
[2] Shandong Univ, Sch Life Sci, Inst Dev Biol, Qingdao 266237, Peoples R China
[3] Shandong Univ, Inst Med Sci, Hosp 2, Jinan 250033, Peoples R China
来源：
DYES AND PIGMENTS | 2020年 / 181卷
基金：
中国国家自然科学基金;
关键词：
Fluorescence; FRET; Ratiometric; Mitochondria-targeted; HSO3-/SO32-; SULFUR-DIOXIDE DERIVATIVES; BORON DIPYRROMETHENE; SELECTIVE DETECTION; HYPOCHLOROUS ACID; BISULFITE; RHODAMINE; CYSTEINE; SULFITE; HYDRAZIDE; PLATFORM;
D O I：
10.1016/j.dyepig.2020.108639
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
We developed a new mitochondria-targeted ratiometric fluorescent probe (named PPA) for SO2 derivatives (HSO3-/SO32-) with a large (pseudo) Stokes shift (209 nm) based on FRET platform in which water-soluble (E)-4-(4-(dimethylamino)styryl)-1-alkylpyridin-1-ium was chosen as acceptor moiety and phenothiazine oxide as donor moiety. Probe PPA showed specific response toward HSO3-/SO32- over H2S, GSH, Cys and Hcy. The recognition group underwent a nucleophilic addition reaction with HSO3-/SO(3)(2- )to give rise to clear dual-emission signal changes in enhanced blue channel and subdued red channel under a single wavelength excitation. Moreover, probe PPA was successfully used for the detection of endogenous HSO3-/SO32- and bioimaging of mitochondria-targeted in living cells.
引用
收藏
页数：6
相关论文
共 50 条
  • [31] Mitochondria-targeted reversible ratiometric fluorescent probe for monitoring SO2/HCHO in living cells
    Zhang T.
    Yin C.
    Zhang Y.
    Chao J.
    Wen G.
    Huo F.
    [J]. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2021, 234
  • [32] Design of mitochondria-targeted colorimetric and ratiometric fluorescent probes for rapid detection of SO2 derivatives in living cells
    Yang, Yutao
    Zhou, Tingting
    Bai, Bozan
    Yin, Caixia
    Xu, Wenzhi
    Li, Wei
    [J]. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2018, 196 : 215 - 221
  • [33] FRET-Based Mitochondria-Targetable Dual-Excitation Ratiometric Fluorescent Probe for Monitoring Hydrogen Sulfide in Living Cells
    Yuan, Lin
    Zuo, Qing-Ping
    [J]. CHEMISTRY-AN ASIAN JOURNAL, 2014, 9 (06) : 1544 - 1549
  • [34] Construction of a FRET-based ratiometric fluorescent thiol probe
    Long, Lingliang
    Lin, Weiying
    Chen, Bingbing
    Gao, Wensha
    Yuan, Lin
    [J]. CHEMICAL COMMUNICATIONS, 2011, 47 (03) : 893 - 895
  • [35] A FRET-based colorimetric and ratiometric fluorescent probe for the detection of Cu2+ with a new trimethylindolin fluorophore
    Zhang, Jiao
    Zhu, Mei
    Jiang, Daoyong
    Zhang, Han
    Li, Luying
    Zhang, Guoning
    Wang, Yucheng
    Feng, Chao
    Zhao, Hong
    [J]. NEW JOURNAL OF CHEMISTRY, 2019, 43 (25) : 10176 - 10182
  • [36] A FRET-based ratiometric two-photon fluorescent probe for superoxide anion detection and imaging in living cells and tissues
    Yao, Shan
    Ma, Chunli
    Lu, Yanbing
    Wei, Xianzhe
    Feng, Xiaowen
    Miao, Pei
    Yang, Guangxin
    Zhang, Jing
    Yan, Mei
    Yu, Jinghua
    [J]. ANALYST, 2019, 144 (05) : 1704 - 1710
  • [37] FRET-based ratiometric fluorescent probe for Cu2+ with a new indolizine fluorophore
    Zheng, Xiaoling
    Ji, Ruixue
    Cao, Xiaoqun
    Ge, Yanqing
    [J]. ANALYTICA CHIMICA ACTA, 2017, 978 : 48 - 54
  • [38] Lysozyme-targeted ratiometric fluorescent probe for SO2 in living cells
    Lu, Yang
    Li, Haidong
    Yao, Qichao
    Sun, Wen
    Fan, Jiangli
    Du, Jianjun
    Wang, Jingyun
    Peng, Xiaojun
    [J]. DYES AND PIGMENTS, 2020, 180
  • [39] A FRET/TICT based multifunctional fluorescent probe for the monitoring of SO2 derivatives and viscosity in living cells and real samples
    Wang, Jianfeng
    Cui, Xiaoling
    Lun, Shenghui
    Yang, Di
    Gao, Chang
    Zhang, Kaiyuan
    Yan, Yehao
    [J]. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2025, 325
  • [40] FRET-based fluorescent ratiometric probes for the rapid detection of endogenous hydrogen sulphide in living cells
    Zhang, Yuming
    Chen, Yuncong
    Bai, Yang
    Xue, Xuling
    He, Weijiang
    Guo, Zijian
    [J]. ANALYST, 2020, 145 (12) : 4233 - 4238
12345