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Univ Tokyo, Div Viral Infect, Dept Infect Dis Control, Int Res Ctr Infect Dis,Inst Med Sci,Minato Ku, Tokyo 1088639, Japan Univ Tokyo, Div Viral Infect, Dept Infect Dis Control, Int Res Ctr Infect Dis,Inst Med Sci,Minato Ku, Tokyo 1088639, Japan