Endotoxin regulates corticotropin-releasing hormone receptor 2 in heart and skeletal muscle

被引：33
|
作者：
Heldwein, KA [1 ]
Duncan, JE [1 ]
Stenzel, P [1 ]
Rittenberg, MB [1 ]
StenzelPoore, MP [1 ]
机构：
[1] OREGON HLTH SCI UNIV,DEPT MOL MICROBIOL & IMMUNOL,PORTLAND,OR 97201
来源：
MOLECULAR AND CELLULAR ENDOCRINOLOGY | 1997年 / 131卷 / 02期
关键词：
corticotropin-releasing hormone; heart; skeletal muscle; endotoxin; receptor; regulation;
D O I：
10.1016/S0303-7207(97)00103-2
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We tested the effect of endotoxin on the peripheral corticotropin-releasing hormone receptor (CRH-R2), which is highly expressed in the heart. Systemic injection of LPS markedly downregulated CRH-R2 mRNA levels in the heart in a dose and time dependent manner. In contrast, CRH-R2 levels in skeletal muscle increased following exposure to endotoxin. These results suggest that CRH-R2 may be differentially regulated in cardiac tissue and skeletal muscle. Finding that CRH-R2 expression in the heart is modulated by endotoxin, a potent inducer of cardiovascular dysregulation, suggests a possible link between CRH and the cardiovascular response to stress. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码：167 / 172
页数：6
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