Post-transcriptional control of gene expression through subcellular relocalization of mRNA binding proteins

被引：20
|
作者：
Cammas, Anne [2 ,3 ,4 ]
Lewis, Stephen M. [1 ,5 ]
Vagner, Stephan [2 ,3 ,4 ]
Holcik, Martin [1 ]
机构：
[1] Univ Ottawa, Dept Paediat, Childrens Hosp Eastern Ontario, Apoptosis Res Ctr,Res Inst, Ottawa, ON K1H 8L1, Canada
[2] INSERM, U563, F-31000 Toulouse, France
[3] Inst Claudius Regaud, F-31000 Toulouse, France
[4] Univ Toulouse 3, F-31000 Toulouse, France
[5] Atlantic Canc Res Inst, Moncton, NB E1C 8X3, Canada
来源：
BIOCHEMICAL PHARMACOLOGY | 2008年 / 76卷 / 11期
基金：
加拿大自然科学与工程研究理事会; 加拿大健康研究院;
关键词：
RNA binding protein; Subcellular localization; Splicing; Translation; IRES; Signaling pathway;
D O I：
10.1016/j.bcp.2008.05.022
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Eukaryotic cells have developed multiple mechanisms to respond to different physiological cues, such as cellular stress, which allow the cells to adapt themselves to their new environment. The regulation of post-transcriptional gene expression is an important component of the cellular stress response and is mediated by mRNA binding proteins (mRBPs). Recently, several studies have shown that regulated subcellular localization of mRBPs upon diverse stimuli (such as cellular stress) provides an additional level of regulation for gene expression. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：1395 / 1403
页数：9
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