Asymmetric synthesis fluorinated cyclopropanes of functionalized and its application to fluoromethano amino acids

被引：0
|
作者：
Taguchi, T
Shibuya, A
Morikawa, T
机构：
来源：
BIOMEDICAL FRONTIERS OF FLUORINE CHEMISTRY | 1996年 / 639卷
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D O I：
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中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Asymmetric syntheses of functionalized fluorinated cyclopropanes developed in our group are described. These are 1) the Simmons-Smith reaction of fluoroallyl alcohol derivatives, 2) difluorocarbene addition to chiral olefins, and 3) utilization of 4-bromo-4,4-difluoro crotonate as a building block. As an application, synthesis of 2-fluoro-2,3-methano-GABA and 3,4-(difluoromethano)glutamic acid is also described.
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页码：73 / 82
页数：10
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