Rapid diastereocontrolled synthesis of 2,2,5-trisubstituted pyrrolidines

被引：16

作者：

Chandan, Nandkishkor ^{[1
]}

Moloney, Mark G. ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2008年 / 6卷 / 20期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1039/b811642c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2,2,5-Trisubstituted pyrrolidines are available from allylic pyroglutamates by Ireland-Claisen ester rearrangement followed by Eschenmoser sulfide contraction and reduction in a highly diastereoselective and efficient sequence. Some of the products from this sequence exhibit activity against S. aureus, but are much less active against E. coli.

引用

页码：3664 / 3666

页数：3

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