Rapid diastereocontrolled synthesis of 2,2,5-trisubstituted pyrrolidines

被引：16
|
作者：
Chandan, Nandkishkor [1 ]
Moloney, Mark G. [1 ]
机构：
[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2008年 / 6卷 / 20期
基金：
英国工程与自然科学研究理事会;
关键词：
D O I：
10.1039/b811642c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2,2,5-Trisubstituted pyrrolidines are available from allylic pyroglutamates by Ireland-Claisen ester rearrangement followed by Eschenmoser sulfide contraction and reduction in a highly diastereoselective and efficient sequence. Some of the products from this sequence exhibit activity against S. aureus, but are much less active against E. coli.
引用
收藏
页码：3664 / 3666
页数：3
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