Black foam films from aqueous solutions of a mixture of phospholipids and a permeation enhancer

被引：4

作者：

Tranchant, JF

Bonté, F

Leroy, S

Nedyalkov, M

Platikanov, D

Javierre, I

Benattar, JJ ^{[1
]}

机构：

[1] CEA Saclay, DSM DRECAM, Serv Phys Etat Condense, F-91191 Gif Sur Yvette, France

[2] LVMH R&D, F-45804 St Jean De Braye, France

[3] Univ Sofia, Dept Phys Chem, BU-1126 Sofia, Bulgaria

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2002年 / 249卷 / 02期

关键词：

black films; bilayers; surface tension; x-ray reflectivity; skin permeability; gas permeability; contact angle;

D O I：

10.1006/jcis.2002.8308

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The influence of a permeation enhancer on the properties of phospholipid black foam films has been studied through the combination of three complementary techniques: surface tension measurements, X-ray reflectivity, and the "diminishing bubble" method. This permeation enhancer is said to optimize the delivery of active ingredients into or through the stratum corneum: the 4-decyl oxazolidin-2-one. We made films of a complex phospholipid mixture that mimic the behavior of the enhancer in a membrane cell. Mixed phospholipids/4-decyl oxazolidin-2-one/NaCl solutions were studied with various 4-decyl oxazolidin-2-one concentrations. Stable black films were obtained and their thicknesses examined. The evolution of the coefficient of gas permeability with 4-decyl oxazolidin-2-one concentration is also addressed. (C) 2002 Elsevier Science (USA).

引用

页码：398 / 404

页数：7

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