Long-term administration of GHB does not affect muscular mass in alcoholics

被引:20
|
作者
Addolorato, G
Capristo, E
Gessa, GL
Caputo, F
Stefanini, GF
Gasbarrini, G
机构
[1] Catholic Univ, Inst Internal Med, I-00168 Rome, Italy
[2] Univ Cagliari, Bernard B Brodie Dept Neurosci, I-09124 Cagliari, Italy
[3] Univ Bologna, Ctr Study & Treatment Alcohol Addict, I-40126 Bologna, Italy
[4] Osped Infermi, Dept Internal Med, Faenza, Italy
关键词
gamma-hydroxybutyric acid; alcoholism therapy; growth hormone; fat-free mass; anabolic effect;
D O I
10.1016/S0024-3205(99)00395-1
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Gamma-hydroxybutyric acid (GHB) is a drug recently utilized for alcoholism management. It has been shown that GHB has anabolic effects since it can increase growth hormone (GH) release in healthy subjects. At present, there are no studies investigating body composition in alcoholics during long-term GHB treatment. In this study body composition and GH secretion in alcohol dependent subjects was evaluated during addiction and at different time of GHB administration and alcohol abstinence. A total of 45 male alcohol dependent patients (mean age 39.7+/-9.8 yrs, mean height: 171+/-6.8 cm, body mass index -BMI- 22.1+/-1.6 kg/m(2)) were consecutively enrolled. Body composition was assessed by anthropometry, bioimpedance analysis and tritiated water method. A 7-day food diary was collected. Plasma GH levels were determined by radioimmunoassay. A 6-month total abstinence was obtained in 22 patients, by means of psychological support counseling and self-help groups in 9 subjects and also by 50 mg/kg/day of GHB in 13 subjects. At 1, 2, 3 and 6 months of abstinence, the biochemical assessment and metabolic variables were re-examined. Fat-free mass (FFM) and basal GH secretion were similar at the different times of follow-up in both groups of patients. GHB treated patients and those receiving psychological support alone showed similar values in FFM and GH. Both groups of patients did not differ in FFM and plasma GH level from healthy controls at any of the times evaluated. Waist-to-hip ratio did not differ between patient groups, while higher values were shown in alcoholics with respect to control subjects. The present study shows that long-term administration of GHB did not affect muscular mass and did not determine an increase of GH release in chronic alcoholics. This findings could be due to an impairment of the hypothalamic-limbic system and of GABAergic neurotransmission in alcoholics' brain. (C) 1999 Elsevier Science Inc.
引用
收藏
页码:PL191 / PL196
页数:6
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