Solvent free synthesis of 3,4-dihydropyrimidine-2-(1H)-ones/thiones catalyzed by N,O-bis(trimethylsilyl)acetamide and dicyclohexyl carbodimide

被引：16
|
作者：
Murthy, Y. L. N. [1 ]
Rajack, Abdul [1 ,2 ]
Yuvaraj, Kanithi [1 ]
机构：
[1] Andhra Univ, Dept Organ Chem Foods Drugs & Water, Visakhapatnam 530003, Andhra Pradesh, India
[2] MVGR Coll Engn, Dept Sci & Humanities, Vijayanagaram 535005, India
来源：
ARABIAN JOURNAL OF CHEMISTRY | 2016年 / 9卷
关键词：
N; O-Bis(trimethylsilyl)acetamide; Dicyclohexyl carbodimide; Solvent free; 3,4-Dihydropyrimidinones; 3,4-Dihydropyrimidithiones; ONE-POT SYNTHESIS; CALCIUM-CHANNEL BLOCKERS; BIGINELLI-TYPE; EFFICIENT SYNTHESIS; REUSABLE CATALYST; GREEN APPROACH; ACID-ESTERS; DIHYDROPYRIMIDINONES; CONDENSATION; 3-COMPONENT;
D O I：
10.1016/j.arabjc.2012.04.046
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report herein, the usage of N,O-bis(trimethylsilyl) acetamide (BSA) and dicyclohexyl carbodimide (DCC) as two new catalysts for three component condensation of an aldehyde, ethyl acetoacetate and urea/thiourea under solvent free conditions at 100 degrees C to afford the corresponding 3,4-dihydropyrimidine-2-(1H)-ones/thiones (DHPMs) in good to excellent yields. A comparative study of these two catalysts was made and presented. (C) 2012 Production and hosting by Elsevier B.V. on behalf of King Saud University.
引用
收藏
页码：S1740 / S1746
页数：7
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