Downregulation of kappa opioid receptor mRNA levels by chronic ethanol and repetitive cocaine in rat ventral tegmentum and nucleus accumbens

被引：60
|
作者：
Rosin, Å
Lindholm, S
Franck, J
Georgieva, J
机构：
[1] Karolinska Inst, Dept Clin Neurosci, Expt Drug Addict Res Sect, S-17176 Stockholm, Sweden
[2] Karolinska Inst, Dept Clin Neurosci, Clin Drug Addict Res Sect, S-17176 Stockholm, Sweden
[3] Karolinska Hosp, Dept Clin Pharmacol, S-17176 Stockholm, Sweden
来源：
NEUROSCIENCE LETTERS | 1999年 / 275卷 / 01期
关键词：
kappa opioid receptor mRNA; 'binge' cocaine; ethanol; competitive polymerase chain reaction; rat; ventral tegmental area; nucleus accumbens;
D O I：
10.1016/S0304-3940(99)00675-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The combination of ethanol and cocaine is commonly abused by human addicts which has serious clinical consequences. Here, the effects of separately and concurrently administered ethanol and 'binge' cocaine on kappa opioid receptor (KOR) mRNA in the ventral tegmental area (VTA) and nucleus accumbens (NAc) of rats were studied. KOR mRNA was down-regulated in both brain regions during concurrent as well as separate treatment with these drugs. In the VTA, the most pronounced decrease was obtained following combined treatment with ethanol and 'binge' cocaine. In the NAc, the strongest decrease was observed in the 'binge' cocaine group. This profound decrease of KOR mRNA in regions important for brain reward suggests a potential role of the KOR system in the abuse of cocaine and ethanol. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
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页码：1 / 4
页数：4
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