Downregulation of kappa opioid receptor mRNA levels by chronic ethanol and repetitive cocaine in rat ventral tegmentum and nucleus accumbens

被引：60
|
作者：
Rosin, Å
Lindholm, S
Franck, J
Georgieva, J
机构：
[1] Karolinska Inst, Dept Clin Neurosci, Expt Drug Addict Res Sect, S-17176 Stockholm, Sweden
[2] Karolinska Inst, Dept Clin Neurosci, Clin Drug Addict Res Sect, S-17176 Stockholm, Sweden
[3] Karolinska Hosp, Dept Clin Pharmacol, S-17176 Stockholm, Sweden
来源：
NEUROSCIENCE LETTERS | 1999年 / 275卷 / 01期
关键词：
kappa opioid receptor mRNA; 'binge' cocaine; ethanol; competitive polymerase chain reaction; rat; ventral tegmental area; nucleus accumbens;
D O I：
10.1016/S0304-3940(99)00675-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The combination of ethanol and cocaine is commonly abused by human addicts which has serious clinical consequences. Here, the effects of separately and concurrently administered ethanol and 'binge' cocaine on kappa opioid receptor (KOR) mRNA in the ventral tegmental area (VTA) and nucleus accumbens (NAc) of rats were studied. KOR mRNA was down-regulated in both brain regions during concurrent as well as separate treatment with these drugs. In the VTA, the most pronounced decrease was obtained following combined treatment with ethanol and 'binge' cocaine. In the NAc, the strongest decrease was observed in the 'binge' cocaine group. This profound decrease of KOR mRNA in regions important for brain reward suggests a potential role of the KOR system in the abuse of cocaine and ethanol. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：1 / 4
页数：4
相关论文
共 50 条
  • [1] Transient upregulation of μ opioid receptor mRNA levels in nucleus accumbens during chronic cocaine administration
    Azaryan, AV
    Clock, BJ
    Rosenberger, JG
    Cox, BM
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1998, 76 (03) : 278 - 283
  • [2] Transient upregulation of mu opioid receptor mRNA in nucleus accumbens during chronic cocaine administration.
    Azaryan, AV
    Clock, BJ
    Cox, BM
    FASEB JOURNAL, 1996, 10 (03): : 2586 - 2586
  • [3] Kappa opioid receptor modulation of the neurochemical effects of ethanol in the nucleus accumbens and central amygdala
    Zapata, A
    Chefer, V
    Gonzales, R
    Shippenberg, TS
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2005, 29 (05) : 181A - 181A
  • [4] THE kappa-opioid receptor in the nucleus accumbens shell: Factors in the effects on ethanol drinking
    Pirino, B. E.
    Carpenter, B. A.
    Candelas, P. G.
    Hawks, A.
    Curtis, G. R.
    Gargiulo, A. T.
    Karkhanis, A. N.
    Barson, J. R.
    ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH, 2023, 47 : 375 - 375
  • [5] The effect of repeated administration of morphine, cocaine and ethanol on mu and delta opioid receptor density in the nucleus accumbens and striatum of the rat
    Turchan, J
    Przewlocka, B
    Toth, G
    Lason, W
    Borsodi, A
    Przewlocki, R
    NEUROSCIENCE, 1999, 91 (03) : 971 - 977
  • [6] The effect of prolonged treatment with imipramine and electroconvulsive shock on the levels of endogenous enkephalins in the nucleus accumbens and the ventral tegmentum of the rat
    DziedzickaWasylewska, M
    Rogoz, R
    JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION, 1995, 102 (03) : 221 - 228
  • [7] Ethanol administration potentiates cocaine-induced dopamine levels in the rat nucleus accumbens
    Lindholm, S
    Rosin, Å
    Dahlin, I
    Georgieva, J
    Franck, J
    BRAIN RESEARCH, 2001, 915 (02) : 176 - 184
  • [8] KAPPA-OPIOID RECEPTOR STIMULATION IN THE NUCLEUS ACCUMBENS AFFECTS PHARMACOLOGICALLY-RELEVANT ETHANOL DRINKING
    Gargiulo, A. T.
    Barson, J. R.
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2018, 42 : 211A - 211A
  • [9] Contrasting effects of 5-HT3 receptor stimulation of the nucleus accumbens or ventral tegmentum on food intake in the rat
    Pratt, Wayne E.
    Lin, Peagan
    Pierce-Messick, Zachary
    Ilesanmi, Adeolu O.
    Clissold, Kara A.
    BEHAVIOURAL BRAIN RESEARCH, 2017, 323 : 15 - 23
  • [10] Distinct Effects of Nalmefene on Dopamine Uptake Rates and Kappa Opioid Receptor Activity in the Nucleus Accumbens Following Chronic Intermittent Ethanol Exposure
    Rose, Jamie H.
    Karkhanis, Anushree N.
    Steiniger-Brach, Bjorn
    Jones, Sara R.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 17 (08):
12345