Metal-Free Synthesis of 2-Fluoroalkylated Quinolines Using Polyfluoroalkanoic Acids as Direct Fluorine Sources

被引：33

作者：

Nan, Jiang ^{[1
]}

Hu, Yan ^{[1
]}

Chen, Pu ^{[1
]}

Ma, Yangmin ^{[1
]}

机构：

[1] Shaanxi Univ Sci & Technol, Coll Chem & Chem Engn, Shaanxi Key Lab Chem Addit Ind, Xian 710021, Shaanxi, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 07期

基金：

中国博士后科学基金;

关键词：

ONE-POT SYNTHESIS; TRIFLUOROACETIC-ACID; 3-COMPONENT SYNTHESIS; FACILE SYNTHESIS; TRIFLUOROMETHYLATION; CYCLIZATION; CHLORIDES; ARYL; DIFLUOROMETHYLATION; BROMIDES;

D O I：

10.1021/acs.orglett.9b00039

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel [5 + 1] cyclization of 2-vinylanilines with polyfluoroalkanoic acids under catalyst- and additive-free conditions was successfully implemented. The approach directly employs very low-cost and readily available polyfluoroalkanoic acids as both Cl synthons and fluoroalkyl building blocks. This method provides concise access to diverse 2-fluoroalkylated (CF3, C2F5, C3F2, CF2H, CF2Cl, and CF2Br) quinolines in good yields with excellent functional group tolerance in high yield on a gram scale.

引用

页码：1984 / 1988

页数：5

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