Delayed Effects of NMDA Receptor Antagonist MK-801 on Storage and Reconsolidation of Spatial Memory in Rats

被引：1
|
作者：
Storozheva, Z. I. [1 ]
Solovieva, O. A. [1 ]
Proshin, A. T. [1 ]
Sherstnev, V. V. [1 ]
机构：
[1] Russian Acad Med Sci, PK Anokhin Inst Normal Physiol, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2012年 / 153卷 / 05期
关键词：
glutamate NMDA glutamat receptors; MK-801; learning; spatial memory; rats; ADULT HIPPOCAMPAL NEUROGENESIS; FIBROBLAST GROWTH FACTOR-2; CONDITIONED FEAR; EXTINCTION; FACILITATE; MODEL;
D O I：
10.1007/s10517-012-1777-6
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the effects of NMDA receptor antagonist MK-801 on the storage and reconsolidation of spatial memory in Morris water maze in adult rats. MK-801 (50 mu g/kg) administered 24 h after the completion of training was shown to improve the resistance of spatial memory to spontaneous extinction, while reminder against the background of MK-801 suppresses its ameliorating effect on memory storage. The detected behavioral effects of MK-801 persisted over 60 days after administration and can be associated with its influence on coupled neurogenesis/apoptosis processes induced during memory trace formation in adult animals.
引用
收藏
页码：605 / 608
页数：4
相关论文
共 50 条
  • [41] A Behavioral Analysis of the Spatial Learning Deficit Induced by the NMDA Receptor Antagonist MK-801 (Dizocilpine) in the Rat
    Maria Åhlander
    Ilga Misane
    Pär A Schött
    Sven Ove Ögren
    [J]. Neuropsychopharmacology, 1999, 21 : 414 - 426
  • [42] A behavioral analysis of the spatial learning deficit induced by the NMDA receptor antagonist MK-801 (dizocilpine) in the rat
    Åhlander, M
    Misane, I
    Schött, PA
    Ögren, SO
    [J]. NEUROPSYCHOPHARMACOLOGY, 1999, 21 (03) : 414 - 426
  • [43] The Effects of Glutamate NMDA Receptor Antagonist MK-801 on Gastrointestinal Motility after Middle Cerebral Artery Occlusion in Rats
    Ameer, Nasir Hussin
    Lee, Jae Hee
    Choi, Myoung Ae
    Jin, Guang-Shi
    Kim, Min Sun
    Park, Byung Rim
    [J]. KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2010, 14 (03): : 151 - 156
  • [44] INHIBITION OF MORPHINE-TOLERANCE AND DEPENDENCE BY THE NMDA RECEPTOR ANTAGONIST MK-801
    TRUJILLO, KA
    AKIL, H
    [J]. SCIENCE, 1991, 251 (4989) : 85 - 87
  • [45] Methylphenidate (MPH) and MK-801, an NMDA receptor antagonist: Shared biological properties
    Husson, I
    Mesples, B
    Medja, F
    Leroux, P
    Kosofsky, BE
    Gressens, P
    [J]. PEDIATRIC RESEARCH, 2004, 55 (04) : 412A - 412A
  • [46] EFFECTS OF THE NMDA ANTAGONISTS CPP AND MK-801 ON DELAYED CONDITIONAL DISCRIMINATION
    TAN, S
    KIRK, RC
    ABRAHAM, WC
    MCNAUGHTON, N
    [J]. PSYCHOPHARMACOLOGY, 1989, 98 (04) : 556 - 560
  • [47] INTERACTION OF THE NMDA RECEPTOR NONCOMPETITIVE ANTAGONIST MK-801 WITH MODEL AND NATIVE MEMBRANES
    MORING, J
    NIEGO, LA
    GANLEY, LM
    TRUMBORE, MW
    HERBETTE, LG
    [J]. BIOPHYSICAL JOURNAL, 1994, 67 (06) : 2376 - 2386
  • [48] Discriminative stimulus effects of the NMDA receptor antagonists MK-801 and CGP 37849 in rats
    Zajaczkowski, W
    Moryl, E
    Papp, M
    [J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1996, 55 (01) : 163 - 168
  • [49] NMDA RECEPTOR ANTAGONIST MK-801 REDUCES ISCHEMIC NEURONAL DYSFUNCTION IN RATS HIPPOCAMPUS - AN ELECTROPHYSIOLOGICAL STUDY
    DALKARA, T
    TAN, E
    ERDEMLI, G
    ONUR, R
    ZILELI, T
    ZILELI, R
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 183 (03) : 949 - 949
  • [50] MK-801 IMPEDES THE ACQUISITION OF A SPATIAL MEMORY TASK IN RATS
    MCLAMB, RL
    WILLIAMS, LR
    NANRY, KP
    WILSON, WA
    TILSON, HA
    [J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1990, 37 (01) : 41 - 45
12345