Diffusion-controlled polymer dissolution and drug release

被引：7
|
作者：
Vrentas, JS [1 ]
Vrentas, CM [1 ]
机构：
[1] Penn State Univ, Dept Chem Engn, University Pk, PA 16802 USA
来源：
JOURNAL OF APPLIED POLYMER SCIENCE | 2004年 / 93卷 / 01期
关键词：
diffusion; drug delivery systems; modeling; theory; amorphous;
D O I：
10.1002/app.20406
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A model is formulated for diffusion-controlled polymer dissolution and simultaneous drug release for amorphous, uncrosslinked polymers. Calculated fractional drug release versus time curves are similar to experimental curves reported in the literature. Solutions of the transport equations provide a way of illustrating how poly-mer type and molecular weight can be used in an attempt to approach a constant drug release rate. (C) 2004 Wiley Periodicals, Inc.
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页码：92 / 99
页数：8
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