Investigation of water-soluble inclusion complex of hypericin with β-cyclodextrin polymer

被引：68

作者：

Zhang, Wang ^{[1
]}

Gong, Xiangdong ^{[1
]}

Cai, Yin ^{[1
]}

Zhang, Chuanli ^{[2
]}

Yu, Xing ^{[2
]}

Fan, Jian ^{[2
]}

Diao, Guowang ^{[1
]}

机构：

[1] Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Jiangsu, Peoples R China

[2] Yangzhou Univ, Coll Med, Yangzhou 225002, Jiangsu, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2013年 / 95卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Hypericin; beta-Cyclodextrin polymer; Inclusion complex; Characterization; GAMMA-CYCLODEXTRIN; BEHAVIOR; TRANSPORT; DELIVERY; BINDING; ACID;

D O I：

10.1016/j.carbpol.2013.03.020

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A water-soluble inclusion complex of hypericin (HY) with beta-cyclodextrin polymer (CDP) was achieved by supramolecular interactions between HY and CDP. The inclusion complex (HY-CDP) was characterized by H-1 NMR, FTIR, and UV-vis spectroscopies. Compared with HY, the water-solubility of HY-CDP was greatly enhanced because of the water-soluble CDP host. The mole ratio of beta-cyclodextrin (beta-CD) unit in CDP to HY was determined as 2:1. At 25 degrees C, the dissociated constant of HY-CDP was measured as 1.47 x 10(-7) mol L-1 by UV-vis spectroscopy. In the formation of inclusion complexes, CDP could overcome the beta-CD drawbacks-such as the poor water-solubility and the restriction of single cavity size, indicating it was able to use as a universal solubilizer for pharmaceutical application. (c) 2013 Elsevier Ltd. All rights reserved.

引用

页码：366 / 370

页数：5

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