Porcine IFI16 Negatively Regulates cGAS Signaling Through the Restriction of DNA Binding and Stimulation
被引:11
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作者:
Zheng, Wanglong
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机构:
Yangzhou Univ, Comparat Med Res Inst, Yangzhou, Peoples R China
Yangzhou Univ, Coll Vet Med, Yangzhou, Peoples R China
Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou, Peoples R China
Joint Int Res Lab Agr & Agri Prod Safety, Yangzhou, Peoples R ChinaYangzhou Univ, Comparat Med Res Inst, Yangzhou, Peoples R China
Zheng, Wanglong
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Zhou, Rongyun
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机构:
Yangzhou Univ, Comparat Med Res Inst, Yangzhou, Peoples R China
Yangzhou Univ, Coll Vet Med, Yangzhou, Peoples R China
Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou, Peoples R China
Joint Int Res Lab Agr & Agri Prod Safety, Yangzhou, Peoples R ChinaYangzhou Univ, Comparat Med Res Inst, Yangzhou, Peoples R China
Zhou, Rongyun
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Li, Shuangjie
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机构:
Yangzhou Univ, Comparat Med Res Inst, Yangzhou, Peoples R China
Yangzhou Univ, Coll Vet Med, Yangzhou, Peoples R China
Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou, Peoples R China
Joint Int Res Lab Agr & Agri Prod Safety, Yangzhou, Peoples R ChinaYangzhou Univ, Comparat Med Res Inst, Yangzhou, Peoples R China
Li, Shuangjie
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He, Shan
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机构:
Yangzhou Univ, Comparat Med Res Inst, Yangzhou, Peoples R China
Yangzhou Univ, Coll Vet Med, Yangzhou, Peoples R China
Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou, Peoples R China
Joint Int Res Lab Agr & Agri Prod Safety, Yangzhou, Peoples R ChinaYangzhou Univ, Comparat Med Res Inst, Yangzhou, Peoples R China
He, Shan
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Luo, Jia
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Yangzhou Univ, Comparat Med Res Inst, Yangzhou, Peoples R China
Yangzhou Univ, Coll Vet Med, Yangzhou, Peoples R China
Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou, Peoples R China
Joint Int Res Lab Agr & Agri Prod Safety, Yangzhou, Peoples R ChinaYangzhou Univ, Comparat Med Res Inst, Yangzhou, Peoples R China
Luo, Jia
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Zhu, Meiqin
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机构:
Yangzhou Univ, Comparat Med Res Inst, Yangzhou, Peoples R China
Yangzhou Univ, Coll Vet Med, Yangzhou, Peoples R China
Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou, Peoples R China
Joint Int Res Lab Agr & Agri Prod Safety, Yangzhou, Peoples R ChinaYangzhou Univ, Comparat Med Res Inst, Yangzhou, Peoples R China
Zhu, Meiqin
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Chen, Nanhua
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机构:
Yangzhou Univ, Comparat Med Res Inst, Yangzhou, Peoples R China
Yangzhou Univ, Coll Vet Med, Yangzhou, Peoples R China
Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou, Peoples R China
Joint Int Res Lab Agr & Agri Prod Safety, Yangzhou, Peoples R ChinaYangzhou Univ, Comparat Med Res Inst, Yangzhou, Peoples R China
Chen, Nanhua
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Chen, Hongjun
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机构:
Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai, Peoples R ChinaYangzhou Univ, Comparat Med Res Inst, Yangzhou, Peoples R China
Chen, Hongjun
[5
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Meurens, Francois
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Oniris, BIOEPAR, INRAE, Nantes, FranceYangzhou Univ, Comparat Med Res Inst, Yangzhou, Peoples R China
Meurens, Francois
[6
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Zhu, Jianzhong
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机构:
Yangzhou Univ, Comparat Med Res Inst, Yangzhou, Peoples R China
Yangzhou Univ, Coll Vet Med, Yangzhou, Peoples R China
Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou, Peoples R China
Joint Int Res Lab Agr & Agri Prod Safety, Yangzhou, Peoples R ChinaYangzhou Univ, Comparat Med Res Inst, Yangzhou, Peoples R China
Zhu, Jianzhong
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机构:
[1] Yangzhou Univ, Comparat Med Res Inst, Yangzhou, Peoples R China
[2] Yangzhou Univ, Coll Vet Med, Yangzhou, Peoples R China
[3] Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou, Peoples R China
[4] Joint Int Res Lab Agr & Agri Prod Safety, Yangzhou, Peoples R China
[5] Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai, Peoples R China
The innate immunity DNA sensors have drawn much attention due to their significant importance against the infections with DNA viruses and intracellular bacteria. Among the multiple DNA sensors, IFI16, and cGAS are the two major ones, subjected to extensive studies. However, these two DNA sensors in livestock animals have not been well defined. Here, we studied the porcine IFI16 and cGAS, and their mutual relationship. We found that both enable STING-dependent signaling to downstream IFN upon DNA transfection and HSV-1 infection, and cGAS plays a major role in DNA signaling. In terms of their relationship, IFI16 appeared to interfere with cGAS signaling as deduced from both transfected and knockout cells. Mechanistically, IFI16 competitively binds with agonist DNA and signaling adaptor STING and thereby influences second messenger cGAMP production and downstream gene transcription. Furthermore, the HIN2 domain of porcine IFI16 harbored most of its activity and mediated cGAS inhibition. Thus, this study provides a unique insight into the porcine DNA sensing system.
机构:
Huazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China
Cooperat Innovat Ctr Sustainable Pig Prod, Wuhan 430070, Peoples R ChinaHuazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China
Zhang, Ruoxi
Fang, Liurong
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机构:
Huazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China
Cooperat Innovat Ctr Sustainable Pig Prod, Wuhan 430070, Peoples R ChinaHuazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China
Fang, Liurong
Wang, Dang
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机构:
Huazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China
Cooperat Innovat Ctr Sustainable Pig Prod, Wuhan 430070, Peoples R ChinaHuazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China
Wang, Dang
Cai, Kaimei
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机构:
Huazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China
Cooperat Innovat Ctr Sustainable Pig Prod, Wuhan 430070, Peoples R ChinaHuazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China
Cai, Kaimei
Zhang, Huan
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机构:
Huazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China
Cooperat Innovat Ctr Sustainable Pig Prod, Wuhan 430070, Peoples R ChinaHuazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China
Zhang, Huan
Xie, Lilan
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机构:
Wuhan Inst Bioengn, Coll Life Sci & Technol, Wuhan 430415, Peoples R ChinaHuazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China
Xie, Lilan
Li, Yi
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Wuhan Inst Bioengn, Coll Life Sci & Technol, Wuhan 430415, Peoples R ChinaHuazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China
Li, Yi
Chen, Huanchun
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机构:
Huazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China
Cooperat Innovat Ctr Sustainable Pig Prod, Wuhan 430070, Peoples R ChinaHuazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China
Chen, Huanchun
Xiao, Shaobo
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Huazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China
Cooperat Innovat Ctr Sustainable Pig Prod, Wuhan 430070, Peoples R ChinaHuazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China
机构:
SAIC Frederick Inc, Frederick Natl Lab Canc Res, Appl & Dev Directorate, Lab Human Retrovirol,Clin Serv Program, Frederick, MD 21702 USASAIC Frederick Inc, Frederick Natl Lab Canc Res, Appl & Dev Directorate, Lab Human Retrovirol,Clin Serv Program, Frederick, MD 21702 USA
Sui, Hongyan
Zhou, Ming
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机构:
SAIC Frederick Inc, Frederick Natl Lab Canc Res, Lab Prote & Analyt Technol, Adv Technol Program, Frederick, MD 21702 USASAIC Frederick Inc, Frederick Natl Lab Canc Res, Appl & Dev Directorate, Lab Human Retrovirol,Clin Serv Program, Frederick, MD 21702 USA
Zhou, Ming
Chen, Qian
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机构:
SAIC Frederick Inc, Frederick Natl Lab Canc Res, Appl & Dev Directorate, Lab Human Retrovirol,Clin Serv Program, Frederick, MD 21702 USASAIC Frederick Inc, Frederick Natl Lab Canc Res, Appl & Dev Directorate, Lab Human Retrovirol,Clin Serv Program, Frederick, MD 21702 USA
Chen, Qian
Lane, H. Clifford
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机构:
NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USASAIC Frederick Inc, Frederick Natl Lab Canc Res, Appl & Dev Directorate, Lab Human Retrovirol,Clin Serv Program, Frederick, MD 21702 USA
Lane, H. Clifford
Imamichi, Tomozumi
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机构:
SAIC Frederick Inc, Frederick Natl Lab Canc Res, Appl & Dev Directorate, Lab Human Retrovirol,Clin Serv Program, Frederick, MD 21702 USASAIC Frederick Inc, Frederick Natl Lab Canc Res, Appl & Dev Directorate, Lab Human Retrovirol,Clin Serv Program, Frederick, MD 21702 USA
机构:
Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Microbiol & Immunol, HM Bligh Canc Res Labs, N Chicago, IL 60064 USARosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Microbiol & Immunol, HM Bligh Canc Res Labs, N Chicago, IL 60064 USA
Dutta, Dipanjan
Dutta, Sujoy
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Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Microbiol & Immunol, HM Bligh Canc Res Labs, N Chicago, IL 60064 USARosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Microbiol & Immunol, HM Bligh Canc Res Labs, N Chicago, IL 60064 USA
Dutta, Sujoy
Veettil, Mohanan Valiya
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Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Microbiol & Immunol, HM Bligh Canc Res Labs, N Chicago, IL 60064 USARosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Microbiol & Immunol, HM Bligh Canc Res Labs, N Chicago, IL 60064 USA
Veettil, Mohanan Valiya
Roy, Arunava
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Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Microbiol & Immunol, HM Bligh Canc Res Labs, N Chicago, IL 60064 USARosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Microbiol & Immunol, HM Bligh Canc Res Labs, N Chicago, IL 60064 USA
Roy, Arunava
Ansari, Mairaj Ahmed
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Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Microbiol & Immunol, HM Bligh Canc Res Labs, N Chicago, IL 60064 USARosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Microbiol & Immunol, HM Bligh Canc Res Labs, N Chicago, IL 60064 USA
Ansari, Mairaj Ahmed
Iqbal, Jawed
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Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Microbiol & Immunol, HM Bligh Canc Res Labs, N Chicago, IL 60064 USARosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Microbiol & Immunol, HM Bligh Canc Res Labs, N Chicago, IL 60064 USA
Iqbal, Jawed
Chikoti, Leela
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Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Microbiol & Immunol, HM Bligh Canc Res Labs, N Chicago, IL 60064 USARosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Microbiol & Immunol, HM Bligh Canc Res Labs, N Chicago, IL 60064 USA
Chikoti, Leela
Kumar, Binod
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Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Microbiol & Immunol, HM Bligh Canc Res Labs, N Chicago, IL 60064 USARosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Microbiol & Immunol, HM Bligh Canc Res Labs, N Chicago, IL 60064 USA
Kumar, Binod
Johnson, Karen E.
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Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Microbiol & Immunol, HM Bligh Canc Res Labs, N Chicago, IL 60064 USARosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Microbiol & Immunol, HM Bligh Canc Res Labs, N Chicago, IL 60064 USA
Johnson, Karen E.
Chandran, Bala
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Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Microbiol & Immunol, HM Bligh Canc Res Labs, N Chicago, IL 60064 USARosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Microbiol & Immunol, HM Bligh Canc Res Labs, N Chicago, IL 60064 USA