Voltammetric behaviour of ketorolac and its HPLC-EC determination in tablets.

被引：7
|
作者：
Squella, JA
Lemus, I
Sturm, JC
NunezVergara, LJ
机构：
[1] Bioelectrochemistry Laboratory, Fac. Chem. and Pharmaceutical Sci., University of Chile, Santiago 1
来源：
ANALYTICAL LETTERS | 1997年 / 30卷 / 03期
关键词：
voltammetry; HPLC; electrochemical detection; ketorolac;
D O I：
10.1080/00032719708001801
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Ketorolac is an antiinflammatory-analgesic agent that is oxidizable at the glassy carbon electrode. The voltammetric oxidation produces two well resolved pH-dependent peaks, that are overlapped at pH>10. Using this voltammetric response a HPLC procedure with electrochemical detection in order to quantify ketorolac in pharmaceutical dosage forms is presented. Furthermore comparative methods using UV spectrophotometry and HPLC with photodiode array detector were used.
引用
收藏
页码：553 / 564
页数：12
相关论文
共 50 条
  • [1] Electrooxidation of pimozide and its differential pulse voltammetric and HPLC-EC determination
    Özkan, SA
    Özkan, Y
    Sentürk, Z
    [J]. ANALYTICA CHIMICA ACTA, 2002, 453 (02) : 221 - 229
  • [2] VOLTAMMETRIC AND HPLC-EC DETERMINATION OF DERIVATIZED BIOMOLECULES HAVING ELECTROACTIVE FUNCTIONAL-GROUPS
    SATO, M
    YAMADA, T
    OOGURO, H
    [J]. JOURNAL OF THE ELECTROCHEMICAL SOCIETY, 1987, 134 (8B) : C501 - C501
  • [3] DETERMINATION OF BOVINE RETINAL MELATONIN WITH HPLC-EC
    HALL, F
    TENGERDY, C
    MORITA, M
    PAUTLER, E
    [J]. CURRENT EYE RESEARCH, 1985, 4 (08) : 847 - 850
  • [4] POLAROGRAPHIC, VOLTAMMETRIC, AND HPLC-EC OF PHARMACEUTICALLY RELEVANT CYCLIC-COMPOUNDS
    BERSIER, PM
    BERSIER, J
    [J]. ELECTROANALYSIS, 1994, 6 (03) : 171 - 191
  • [5] A MICROMETHOD FOR TRYPTOPHAN DETERMINATION IN BIOLOGICAL-FLUIDS BY HPLC-EC
    NARASIMHACHARI, N
    ETTIGI, P
    PANDURANGI, A
    [J]. FEDERATION PROCEEDINGS, 1986, 45 (03) : 158 - 158
  • [6] Quantitative analysis of the loop diuretic torasemide in tablets and human urine by HPLC-EC
    Barroso, MB
    Alonso, RM
    Jimenez, RM
    [J]. JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 1996, 19 (02) : 179 - 186
  • [7] Improved HPLC method for the determination of impurities in pyridostigmine bromide tablets.
    Rossi, LJ
    Saudarg, DE
    Varnum, SA
    Ali, SN
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 228 : U126 - U126
  • [8] Voltammetric behaviour of clonixin and its differential pulse polarographic determination in tablets
    Alvarez-Lueje, A
    Sturm, JC
    Núñez-Vergara, LJ
    Carbajo, J
    Squella, JA
    [J]. ANALYTICAL LETTERS, 2000, 33 (01) : 53 - 68
  • [9] Simultaneous determination of serotonin, catecholamines and metabolites by HPLC-EC using glutathione as a stabilizer
    Lo, ES
    Verzosa, S
    Fein, A
    Copper, TB
    [J]. JOURNAL OF NEUROCHEMISTRY, 2004, 88 : 72 - 72
  • [10] Simultaneous determination of the diuretics triamterene and furosemide in pharmaceutical formulations and urine by HPLC-EC
    Barroso, MB
    Alonso, RM
    Jimenez, RM
    [J]. JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 1996, 19 (02) : 231 - 246
12345