Synthesis of 1,2,3-Triazole Derivatives

Much attention has been paid to the synthesis of 1,2,3-trizaole derivatives with the development of its wide applications in the fields of medicine, pesticide, and materials. This review describs the synthesis history of the 1,2,3-triazole derivatives and focuses on Cu-catalyzed synthesis of 1,4-disubstitued-1,2,3-triazoles, Ru-catalyzed synthesis of 1, 5-disubstitued-1, 2, 3-triazoles, and other new methods in recent 10 years. Relevant mechanisms and applications of some reactions are also described. Finally, the further work needed to do and the development trends in the field of 1,2,3-triazole derivative synthesis are proposed.