The molecular and genetic basis of antifungal resistance in the emerging fungal pathogen Candida auris

被引：27
|
作者：
Rybak, Jeffrey M. [1 ]
Cuomo, Christina A. [2 ]
Rogers, P. David [1 ]
机构：
[1] St Jude Childrens Res Hosp, Dept Pharm & Pharmaceut Sci, Memphis, TN 38105 USA
[2] Broad Inst MIT & Harvard, Infect Dis & Microbiome Program, Cambridge, MA USA
来源：
CURRENT OPINION IN MICROBIOLOGY | 2022年 / 70卷
基金：
美国国家卫生研究院;
关键词：
ECHINOCANDIN; MUTATIONS;
D O I：
10.1016/j.mib.2022.102208
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Fungal infections are responsible for significant morbidity and mortality. Resistance to the limited number of agents in the antifungal armamentarium among pathogenic fungi represents a growing public health threat. Particularly concerning is the exhibits resistance to the triazole class of antifungals and amphotericin B, and for which isolates resistant to all of the major antifungal classes have been reported. In this brief review, we provide an overview of what is currently known about the molecular and genetic basis for antifungal resistance in this fungal pathogen.
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页数：8
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