Methylated β-cyclodextrin as P-gp modulators for deliverance of doxorubicin across an in vitro model of blood-brain barrier

被引：45
|
作者：
Tilloy, S
Monnaert, V
Fenart, L
Bricout, H
Cecchelli, R
Monflier, E
机构：
[1] Univ Artois, CNRS, FRE 2485, Lab Physicochim Interfaces & Applicat, F-62307 Lens, France
[2] Univ Artois, Fac Sci Jean Perrin, Blood Brain Barrier Lab, EA 2465, F-62307 Lens, France
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 08期
关键词：
cyclodextrin; doxorubicin; P-glycoprotein; blood-brain barrier; cholesterol;
D O I：
10.1016/j.bmcl.2006.01.049
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Co-incubations of various beta-cyclodextrins and doxorubicin have been evaluated on an in vitro model of blood-brain barrier in order to increase the delivery of this P-gp substrate to the brain. Among these cyclodextrins used, the Rame-beta-cyclodextrin and Crysme-beta-cyclodextrin increased the transport by a factor of 2 and 3.7, respectively. This increase was attributed to the cholesterol extraction property of these cyclodextrins from brain capillary endothelial cells leading to a modulation of the P-gp activity. (C) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2154 / 2157
页数：4
相关论文
共 50 条
  • [21] An Electrically Tight In Vitro Blood-Brain Barrier Model Displays Net Brain-to-Blood Efflux of Substrates for the ABC Transporters, P-gp, Bcrp and Mrp-1
    Helms, Hans Christian
    Hersom, Maria
    Kuhlmann, Louise Borella
    Badolo, Lasina
    Nielsen, Carsten Uhd
    Brodin, Birger
    AAPS JOURNAL, 2014, 16 (05): : 1046 - 1055
  • [22] The aryl hydrocarbon receptor (AhR) upregulates P-glycoprotein (P-gp) at the blood-brain barrier (BBB)
    Miller, David S.
    Wang, Xueqian
    FASEB JOURNAL, 2010, 24
  • [23] Quaternary Ammonium β-Cyclodextrin Nanoparticles for Enhancing Doxorubicin Permeability across the In Vitro Blood-Brain Barrier (vol 10, pg 506, 2009)
    Gil, Eun Seok
    Li, Jianshu
    Xiao, Huining
    Lowe, Tao Lu
    BIOMACROMOLECULES, 2009, 10 (04) : 1020 - 1020
  • [24] Transport of Arylsulfatase A across the Blood-Brain Barrier in Vitro
    Matthes, Frank
    Woelte, Philipp
    Boeckenhoff, Annika
    Huewel, Sabine
    Schulz, Mareike
    Hyden, Pia
    Fogh, Jens
    Gieselmann, Volkmar
    Galla, Hans-Joachim
    Matzner, Ulrich
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (20) : 17487 - 17494
  • [25] The blood-brain barrier studied in vitro across species
    Thomsen, Maj Schneider
    Humle, Nanna
    Hede, Eva
    Moos, Torben
    Burkhart, Annette
    Thomsen, Louiza Bohn
    PLOS ONE, 2021, 16 (03):
  • [26] Transport of amentoflavone across the blood-brain barrier in vitro
    Gutmann, H
    Bruggisser, R
    Schaffner, W
    Bogman, K
    Botomino, A
    Drewe, J
    PLANTA MEDICA, 2002, 68 (09) : 804 - 807
  • [27] MORPHINE MODULATES DOXORUBICIN UPTAKE: CYTOFLUORIMETRIC STUDY ON AN IN VITRO MODEL OF BLOOD-BRAIN BARRIER
    Iorio, Anna Lisa
    Da Ros, Martina
    Lucchesi, Maurizio
    Guidi, Milena
    Fonte, Carla
    Favre, Claudio
    Genitori, Lorenzo
    Sardi, Iacopo
    NEURO-ONCOLOGY, 2016, 18 : 141 - 141
  • [28] Involvement of P-glycoprotein in an in vitro blood-brain barrier model
    Joly, B
    Lecureur, V
    Puozzo, C
    Guillouzo, A
    Fardel, O
    INTERNATIONAL JOURNAL OF ONCOLOGY, 1996, 9 (05) : 1029 - 1033
  • [29] P-glycoprotein activity in an in vitro blood-brain barrier model
    Joly, B
    Fardel, O
    Lecureur, V
    Chesne, C
    Puozzo, C
    Guillouzo, A
    BIOLOGY AND PHYSIOLOGY OF THE BLOOD-BRAIN BARRIER: TRANSPORT, CELLULAR INTERACTIONS, AND BRAIN PATHOLOGIES, 1996, 46 : 191 - 196
  • [30] Transcellular Model for Neutral and Charged Nanoparticles Across an In Vitro Blood-Brain Barrier
    Zhang, Lin
    Fan, Jie
    Li, Guanglei
    Yin, Zhaokai
    Fu, Bingmei M.
    CARDIOVASCULAR ENGINEERING AND TECHNOLOGY, 2020, 11 (06) : 607 - 620
12345