Harms of TNF inhibitors in rheumatic diseases: a focused review of the literature

被引：1

作者：

Jain, Archana ^{[1
]}

Singh, Jasvinder A. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Alabama Birmingham, Sch Med, Dept Med, Birmingham, AL USA

[2] Univ Alabama Birmingham, Sch Publ Hlth, Div Epidemiol, Birmingham, AL 35294 USA

[3] Birmingham VA Med Ctr, Med Serv, Birmingham, AL USA

[4] Birmingham VA Med Ctr, Ctr Surg Med Acute Care Res & Transit, Birmingham, AL USA

[5] Mayo Clin, Coll Med, Dept Orthoped Surg, Rochester, MN USA

来源：

IMMUNOTHERAPY | 2013年 / 5卷 / 03期

关键词：

adverse effect; biologic; harm; rheumatic disease; rheumatoid arthritis; TNF biologic; TNF inhibitor; TUMOR-NECROSIS-FACTOR; SERIOUS BACTERIAL-INFECTIONS; MODIFYING ANTIRHEUMATIC DRUGS; FACTOR THERAPY; BRITISH-SOCIETY; HEART-FAILURE; FACTOR ANTAGONISTS; OPPORTUNISTIC INFECTIONS; BIOLOGICS REGISTER; ELDERLY-PATIENTS;

D O I：

10.2217/IMT.13.10

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A focused review of the risk of harms of anti-TNF inhibitors in adult rheumatic diseases was performed. An increased risk of serious infections, tuberculosis and other opportunistic infections has been reported across various studies, with etanercept appearing to have a modestly better safety profile in terms of tuberculosis and opportunistic infections, and infliximab posing a higher risk of serious infections. Evidence suggests no increase in risk of cancer with anti-TNF biologics, but there is an increased risk of non-melanoma skin cancer. Elderly patients appear to be at increased risk of incident or worsening heart failure with anti-TNF biologic use.

引用

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页码：265 / 299

页数：35

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