One case of Felty's syndrome efficiently treated with rituximab

被引：7
|
作者：
Tomi, Anne-Laurence [1 ]
Liote, Frederic [1 ,2 ]
Ea, Hang-Korng [1 ,2 ]
机构：
[1] Hop Lariboisiere, Ctr Viggo Petersen, Dept Rheumatol, F-75010 Paris, France
[2] Univ Paris Diderot, INSERM, U606, F-75010 Paris, France
来源：
JOINT BONE SPINE | 2012年 / 79卷 / 06期
关键词：
Rheumatoid arthritis; Rituximab; Felty's syndrome; B lymphocytes; Anti-TNF; BENEFICIAL RESPONSE; EFFICACY;
D O I：
10.1016/j.jbspin.2012.01.013
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Felty's syndrome (FS) is a rare association of rheumatoid arthritis (RA), neutropenia and splenomegaly. Mechanisms of neutropenia in FS are unclear but involve both innate and humoral immunity, impaired granulopoiesis and decreased granulocyte half-life. Several treatments have been used without clear efficiency. We report a patient with FS efficiently treated with rituximab (RTX), the monoclonal anti-CD20 antibody. A literature review of FS treated with RTX was performed. (C) 2012 Published by Elsevier Masson SAS on behalf of the Societe Francaise de Rhumatologie.
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页码：624 / 625
页数：2
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