Activin pathway enhances colorectal cancer stem cell self-renew and tumor progression

被引：9
|
作者：
Liu, Rui [1 ,2 ]
Wang, Jun-Hua [3 ]
Xu, Chengxiong [4 ,5 ]
Sun, Bo [2 ,3 ]
Kang, Sa-Ouk [1 ,2 ]
机构：
[1] Seoul Natl Univ, Sch Biol Sci, Biophys Lab, Seoul 151742, South Korea
[2] Seoul Natl Univ, Inst Microbiol, Seoul 151742, South Korea
[3] Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China
[4] Third Mil Med Univ, Doping Hosp, Ctr Canc, Chongqing 400042, Peoples R China
[5] Third Mil Med Univ, Inst Surg Res, Chongqing 400042, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2016年 / 479卷 / 04期
关键词：
Colorectal cancer; Cancer stem cells; Activin; TGF-beta; Cancer therapy; GROWTH-INHIBITION; SIGNALING PATHWAY; BREAST; FAMILY; DIFFERENTIATION; PROLIFERATION; HETEROGENEITY; NANOG;
D O I：
10.1016/j.bbrc.2016.09.146
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Activin belongs to transforming growth factor (TGF)-beta super family of growth and differentiation factors and activin pathway participated in broad range of cell process. Studies elaborated activin pathway maintain pluripotency in human stem cells and suggest that the function of activin/nodal signaling in self-renew would be conserved across embryonic and adult stem cells. In this study, we tried to determine the effect of activin signaling pathway in regulation of cancer stem cells as a potential target for cancer therapy in clinical trials. A population of colorectal cancer cells was selected by the treatment of activin A. This population of cell possessed stem cell character with sphere formation ability. We demonstrated activin pathway enhanced the colorectal cancer stem cells self-renew and contribute to colorectal cancer progression in vivo. Targeting activin pathway potentially provide effective strategy for colorectal cancer therapy. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：715 / 720
页数：6
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