2020 update on the renin-angiotensin-aldosterone system in pediatric kidney disease and its interactions with coronavirus

被引：28

作者：

Simoes e Silva, Ana Cristina ^{[1
,2
]}

Lanza, Katharina ^{[1
]}

Palmeira, Vitoria Andrade ^{[1
]}

Costa, Larissa Braga ^{[1
]}

Flynn, Joseph T. ^{[3
]}

机构：

[1] Fed Univ Minas Gerais UFMG, Interdisciplinary Lab Med Invest, Fac Med, Ave Alfredo Balena 190,2nd Floor,Room 281, BR-30130100 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Fac Med, Pediat Nephrol Unit, Dept Pediat, Belo Horizonte, MG, Brazil

[3] Univ Washington, Sch Med, Seattle Childrens Hosp, Pediat Nephrol, Seattle, WA 98105 USA

来源：

PEDIATRIC NEPHROLOGY | 2021年 / 36卷 / 06期

关键词：

Ang II; Ang-(1-7); ACE; ACE2; Chronic kidney disease; Hypertension; COVID-19; Children; CONVERTING ENZYME 2; II TYPE-1 RECEPTOR; DIABETIC-NEPHROPATHY; RAT ANGIOTENSINOGEN; BLOOD-PRESSURE; UP-REGULATION; IN-VIVO; HYPERTENSION; INFLAMMATION; ACE2;

D O I：

10.1007/s00467-020-04759-1

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The last decade was crucial for our understanding of the renin-angiotensin-aldosterone system (RAAS) as a two-axis, counter-regulatory system, divided into the classical axis, formed by angiotensin-converting enzyme (ACE), angiotensin II (Ang II), and the angiotensin type 1 receptor (AT1R), and the alternative axis comprising angiotensin-converting enzyme 2 (ACE2), angiotensin-(1-7) (Ang-(1-7)), and the Mas receptor. Breakthrough discoveries also took place, with other RAAS endopeptides being described, including alamandine and angiotensin A. In this review, we characterize the two RAAS axes and the role of their components in pediatric kidney diseases, including childhood hypertension (HTN), pediatric glomerular diseases, congenital abnormalities of the kidney and urinary tract (CAKUT), and chronic kidney disease (CKD). We also present recent findings on potential interactions between the novel coronavirus, SARS-CoV-2, and components of the RAAS, as well as potential implications of coronavirus disease 2019 (COVID-19) for pediatric kidney diseases.

引用

页码：1407 / 1426

页数：20

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