The Association of Raynaud Syndrome With β-Blockers: A Meta-Analysis

被引：18
|
作者：
Mohokum, Melvin [1 ]
Hartmann, Peter [1 ]
Schlattmann, Peter [2 ]
机构：
[1] Charite, Dept Biometry & Clin Epidemiol, D-10098 Berlin, Germany
[2] Univ Jena, Univ Hosp, Dept Med Stat Comp Sci & Documentat, Jena, Germany
来源：
ANGIOLOGY | 2012年 / 63卷 / 07期
关键词：
beta-blockers; beta-blocking drugs; meta-analysis; prevalence; Raynaud phenomenon; PREVALENCE; HYPERTENSION; POPULATION;
D O I：
10.1177/0003319711432861
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Vasospastic disorders of the digital circulation such as the Raynaud syndrome (RS) are known side effects of treatment of beta-adrenergic blockade. The prevalence of RS in patients during treatment with beta-blockers is not well defined. The objective of this meta-analysis is to assess the prevalence of RS in patients receiving beta-blockers. A literature search was performed for studies dealing with RS and patients receiving beta-blockers. The studies provided sufficient data to estimate the prevalence of RS in patients receiving beta-blockers. A total of 13 eligible studies, contributing data on 1012 individuals, were included in this meta-analysis. For RS in patients receiving beta-blockers, a pooled prevalence of 14.7% (95% confidence interval 0.076-0.236) were obtained. Statistically publication bias was not present (P = .877). Despite some heterogeneity, there is a possible indication of an association between RS and patients receiving beta-blockers.
引用
收藏
页码：535 / 540
页数：6
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