Monocyte chemotactic protein-1 in the vitreous of patients with proliferative diabetic retinopathy

被引：85

作者：

Mitamura, Y

Takeuchi, S

Matsuda, A

Tagawa, Y

Mizue, Y

Nishihira, J

机构：

[1] Toho Univ, Sakura Hosp, Dept Ophthalmol, Chiba 2858741, Japan

[2] Hokkaido Univ, Sch Med, Dept Ophthalmol, Sapporo, Hokkaido 060, Japan

[3] Hokkaido Univ, Sch Med, Cent Res Inst, Sapporo, Hokkaido 060, Japan

[4] Sapporo Immunodiagnost Lab, Sapporo, Hokkaido, Japan

来源：

OPHTHALMOLOGICA | 2001年 / 215卷 / 06期

关键词：

monocyte chemotactic protein-1; proliferative diabetic retinopathy; vitreous; proliferative membrane; retinal photocoagulation;

D O I：

10.1159/000050900

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To investigate the correlation between monocyte chemotactic protein-1 (MCP-1) levels in the vitreous and clinical findings in eyes with proliferative diabetic retinopathy (PDR). Methods: We assayed MCP-1 levels by ELISA in vitreous samples of 88 consecutive patients with PDR (52 eyes) and macular holes or idiopathic epimacular membrane (controls, 36 eyes). Results:The level of MCP-1 in the vitreous was 2,097.5 +/- 1,099.4 pg/ml (mean SD) in PDR, and 504.3 +/- 405.6 pg/ml in the controls. In PDR eyes, multivariate regression analysis revealed a significant association between MCP-1 levels in the vitreous and the degree of proliferative membrane, and a significant negative association between MCP-1 levels and the extent of preoperative retinal photocoagulation. Conclusion: The results suggest that MCP-1 may play a role in the development of the proliferative phase of PDR. Copyright (C) 2001 S. Karger AG, Basel.

引用

页码：415 / 418

页数：4

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