Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines

被引：72

作者：

Bai, NS

Lai, CS

He, K

Zhou, Z

Zhang, L

Quan, Z

Zhu, NQ

Zheng, QY

Pan, MH

Ho, CT

机构：

[1] Rutgers State Univ, Dept Food Sci, New Brunswick, NJ 08901 USA

[2] Natl Kaohsiung Marine Univ, Dept Seafood Sci, Kaohsiung, Taiwan

[3] PureWorld Bot Inc, S Hackensack, NJ 07606 USA

[4] Fudan Univ, Coll Pharm, Shanghai 200032, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 04期

关键词：

D O I：

10.1021/np050437q

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new sesquiterpenes (1-3), together with four known sesquiterpene lactones, were isolated from the flowers of Inula britannica var. chinensis. Structures were established on the basis of high-field 1D and 2D NMR methods supported by HRMS. All sesquiterpene lactones were tested for cytotoxicity as well as apoptotic ratio in human COLO 205, HT 29, HL-60, and AGS cancer cells. Compounds 3 and 4, two alpha-methylene gamma-lactone-bearing sesquiterpenes, were modestly active in these assays.

引用

页码：531 / 535

页数：5

共 50 条

[31] Cytotoxic and apoptotic effects of synthetic benzochromene derivatives on human cancer cell lines
Kheirollahi, Asma
Pordeli, Mahboobeh
Safavi, Maliheh
Mashkouri, Sara
Naimi-Jamal, M. Reza
Ardestani, Sussan Kabudanian
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2014, 387 (12) : 1199 - 1208
[32] Antitumour Activities of Sesquiterpene Lactones from Inula helenium and Inula japonica
Li, Yong
Ni, Zhi-Yu
Zhu, Meng-Chu
Dong, Mei
Wang, Si-Ming
Shi, Qing-Wen
Zhang, Man-Li
Wang, Yu-Fang
Huo, Chang-hong
Kiyota, Hiromasa
Cong, Bin
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, 2012, 67 (7-8): : 375 - 380
[33] Cytotoxic and apoptotic effects of synthetic benzochromene derivatives on human cancer cell lines
Asma Kheirollahi
Mahboobeh Pordeli
Maliheh Safavi
Sara Mashkouri
M. Reza Naimi-Jamal
Sussan Kabudanian Ardestani
Naunyn-Schmiedeberg's Archives of Pharmacology, 2014, 387 : 1199 - 1208
[34] Bioactive sesquiterpene lactones from Centaurea species and their cytotoxic/cytostatic activity against human cell lines in vitro
Koukoulitsa, E
Skaltsa, H
Karioti, A
Demetzos, C
Dimas, K
PLANTA MEDICA, 2002, 68 (07) : 649 - 652
[35] Sesquiterpene lactones from Inula montana L.
González-Romero, MA
Villaescusa-Castillo, L
Díaz-Lanza, AM
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, 2000, 55 (9-10): : 697 - 700
[36] Antiproliferative sesquiterpene lactones from the roots of Inula helenium
Konishi, T
Shimada, Y
Nagao, T
Okabe, H
Konoshima, T
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2002, 25 (10) : 1370 - 1372
[37] Sesquiterpene Lactones from Inula oculus-christi
Mosaddegh, Mahmoud
Moghadam, Maryam Hamzeloo
Ghafari, Saeedeh
Naghibi, Farzaneh
Ostad, Seyed Nasser
Read, Roger W.
NATURAL PRODUCT COMMUNICATIONS, 2010, 5 (04) : 511 - 514
[38] New sesquiterpene lactones from Inula montbretiana DC
Gokbulut, A.
Sarer, E.
Schmidt, T.
PLANTA MEDICA, 2010, 76 (12) : 1267 - 1267
[39] Five new sesquiterpene lactones from Inula hupehensis
Ren, Jie
Qin, Jiang Jiang
Cheng, Xiang Rong
Yan, Shi Kai
Jin, Hui Zi
Zhang, Wei Dong
ARCHIVES OF PHARMACAL RESEARCH, 2013, 36 (11) : 1319 - 1325
[40] Semisynthesis and in vitro cytotoxic evaluation of new analogues of 1-O-acetylbritannilactone, a sesquiterpene from Inula britannica
Dong, Shuai
Tang, Jiang-Jiang
Zhang, Cheng-Chen
Tian, Jun-Mian
Guo, Jun-Tao
Zhang, Qiang
Li, He
Gao, Jin-Ming
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 80 : 71 - 82

← 1 2 3 4 5 →