Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines

被引：72
|
作者：
Bai, NS
Lai, CS
He, K
Zhou, Z
Zhang, L
Quan, Z
Zhu, NQ
Zheng, QY
Pan, MH
Ho, CT
机构：
[1] Rutgers State Univ, Dept Food Sci, New Brunswick, NJ 08901 USA
[2] Natl Kaohsiung Marine Univ, Dept Seafood Sci, Kaohsiung, Taiwan
[3] PureWorld Bot Inc, S Hackensack, NJ 07606 USA
[4] Fudan Univ, Coll Pharm, Shanghai 200032, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 04期
关键词：
D O I：
10.1021/np050437q
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Three new sesquiterpenes (1-3), together with four known sesquiterpene lactones, were isolated from the flowers of Inula britannica var. chinensis. Structures were established on the basis of high-field 1D and 2D NMR methods supported by HRMS. All sesquiterpene lactones were tested for cytotoxicity as well as apoptotic ratio in human COLO 205, HT 29, HL-60, and AGS cancer cells. Compounds 3 and 4, two alpha-methylene gamma-lactone-bearing sesquiterpenes, were modestly active in these assays.
引用
收藏
页码：531 / 535
页数：5
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