The Use of Decellularized Human Placenta in Full-Thickness Wound Repair and Periarticular Soft Tissue Reconstruction An Update on Regenerative Healing

被引:12
|
作者
Brigido, Stephen A. [1 ]
Carrington, Scott C. [1 ]
Protzman, Nicole M. [2 ]
机构
[1] Coordinated Hlth, Foot & Ankle Dept, Foot & Ankle Reconstruct, 2775 Schoenersville Rd, Bethlehem, PA 18017 USA
[2] Coordinated Hlth, Clin Integrat Dept, 3435 Winchester Rd, Allentown, PA 18104 USA
关键词
Amniotic membrane; Extracellular matrix; Growth factors; Placenta; Regenerative healing; PLANTAR HEEL PAIN; CORTICOSTEROID INJECTION; AMNIOTIC MEMBRANE; STEM-CELLS; FOLLOW-UP; FASCIITIS; MATRIX; BIOLOGY;
D O I
10.1016/j.cpm.2017.08.010
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Prolonged or incomplete healing of the foot and ankle can pose significant challenges. Therefore, investigators have begun searching for alternative treatment strategies. With advances in tissue engineering, decellularized human placental connective tissue matrix has been suggested as a means to achieve more rapid and complete healing for various soft tissue and bone procedures. Basic science and clinical studies have shown that decellularized human placental connective tissue matrix can support regenerative healing through cellular migration, accelerated tissue remodeling, and the establishment of functional tissue. Additional research is needed to fully explore and evaluate clinical applications within the foot and ankle.
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页码:95 / +
页数:11
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