Capsazepine partially inhibits neurally mediated gastric mucus secretion following activation of protease-activated receptor 2

被引：17

作者：

Kawabata, A ^{[1
]}

Kinoshita, M ^{[1
]}

Kuroda, R ^{[1
]}

Kakehi, K ^{[1
]}

机构：

[1] Kinki Univ, Fac Pharmaceut Sci, Higashiosaka, Osaka 5778502, Japan

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2002年 / 29卷 / 04期

关键词：

protease-activated receptor-2; vanilloid receptor 1;

D O I：

10.1046/j.1440-1681.2002.03641.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Protease-activated receptor 2 (PAR2), present in capsaicin-sensitive sensory neurons, induces gastric mucus secretion and mucosal cytoprotection. 2. We studied the possible cross-talk between PAR2 and vanilloid receptor 1 (VR1). The VR1 antagonist capsazepine partially inhibited the PAR2-mediated increase in gastric mucus secretion. 3. Thus, activation of VR1 is responsible, at least in part, for the neurally mediated mucosal cytoprotection following activation of PAR2.

引用

页码：360 / 361

页数：2

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