p38 mitogen-activated protein kinase and pain

被引：60
|
作者：
Mai, Lijia [1 ,2 ]
Zhu, Xiao [3 ]
Huang, Fang [2 ]
He, Hongwen [2 ]
Fan, Wenguo [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Hosp Stomatol, Guanghua Sch Stomatol, Dept Anesthesiol, Guangzhou 510080, Peoples R China
[2] Guangdong Prov Key Lab Stomatol, Guangzhou 510080, Peoples R China
[3] Guangdong Med Univ, Marine Biomed Res Inst, Zhanjiang 524023, Peoples R China
来源：
LIFE SCIENCES | 2020年 / 256卷
基金：
中国国家自然科学基金;
关键词：
p38 MAP kinase; Glial cells; Pain; NECROSIS-FACTOR-ALPHA; DORSAL-ROOT GANGLION; SPINAL MICROGLIA CONTRIBUTES; NF-KAPPA-B; INDUCED MECHANICAL HYPERSENSITIVITY; CHRONIC CONSTRICTION INJURY; PRIMARY AFFERENT NEURONS; PERIPHERAL-NERVE INJURY; PRIMARY SENSORY NEURONS; SATELLITE GLIAL-CELLS;
D O I：
10.1016/j.lfs.2020.117885
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Inflammatory and neuropathic pain is initiated by tissue inflammation and nerve injury, respectively. Both are characterized by increased activity in the peripheral and central nervous system, where multiple inflammatory cytokines and other active molecules activate different signaling pathways that involve in the development and/or maintenance of pain. P38 mitogen-activated protein kinase (MAPK) is one member of the MAPK family, which is activated in neurons and glia and contributes importantly to inflammatory and neuropathic pain. The aim of this review is to summarize the latest advances made about the implication of p38 MAPK signaling cascade in pain. It can deepen our understanding of the molecular mechanisms of pain and may help to offer new targets for pain treatment.
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页数：9
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