Effects of Sodium dependent Glucose Transporter 2 (SGLT2) Inhibition with Empagliflozin on Oxidative Stress and Endothelial Dysfunction in STZ-Induced Type I Diabetic Rat

被引:0
|
作者
Oelze, Matthias [1 ]
Kroeller-Schoen, Swenja [1 ]
Mikhed, Yulyia [1 ]
Mader, Michael [1 ]
Zinssius, Elena [1 ]
Stamm, Paul [1 ]
Hausding, Michael [1 ]
Mayoux, Eric [2 ]
Wenzel, Philip [1 ]
Schulz, Eberhard [1 ]
Muenzel, Thomas [1 ]
Daiber, Andreas [1 ]
机构
[1] Johannes Gutenberg Univ Mainz, Mainz, Germany
[2] Boehringer Ingelheim Pharma GmbH & Co KG, Ingelheim, Germany
关键词
D O I
10.1016/j.freeradbiomed.2013.10.459
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
45
引用
收藏
页码:S31 / S32
页数:2
相关论文
共 50 条
  • [31] SGLT2 Inhibition via Dapagliflozin Improves Generalized Vascular Dysfunction in Type 2 Diabetic Mice
    Battson, Micah L.
    Lee, Dustin M.
    Hou, Shuofei
    Jarrell, Dillon K.
    Ecton, Kayl
    Gentile, Christopher L.
    DIABETES, 2017, 66 : LB45 - LB45
  • [32] Random-walk model of the sodium-glucose transporter SGLT2 with stochastic steps and inhibition
    Barreto, Yan B.
    Alencar, Adriano M.
    JOURNAL OF PHYSICS-CONDENSED MATTER, 2022, 34 (18)
  • [33] Pharmacoeconomic evaluation of sodium-glucose transporter-2 (SGLT2) inhibitors for the treatment of type 2 diabetes
    Rahman, Wedad
    Solinsky, Paul Joseph
    Munir, Kashif M.
    Lamos, Elizabeth M.
    EXPERT OPINION ON PHARMACOTHERAPY, 2019, 20 (02) : 151 - 161
  • [34] Administration of SGLT2 inhibitor empagliflozin against TNF-α induced endothelial dysfunction in human venous and arterial endothelial cells
    Uthman, L.
    Homayr, A.
    Hollmann, M. W.
    Zuurbier, C. J.
    Albrecht, M.
    Weber, N. C.
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2018, 120 : 25 - 25
  • [35] The Effects of Empagliflozin, an SGLT2 Inhibitor, on Pancreatic β-Cell Mass and Glucose Homeostasis in Type 1 Diabetes
    Cheng, Sam Tsz Wai
    Chen, Lihua
    Li, Stephen Yu Ting
    Mayoux, Eric
    Leung, Po Sing
    PLOS ONE, 2016, 11 (01):
  • [36] Reduction of sodium dependent glucose transporter SGLT2 expression with an antisense oligonucleotide (ASO) optimized to target the kidney results in significant glucose lowering effects in diabetic mice
    Watts, LM
    Leedom, TA
    Wancewicz, EV
    Siwkowski, AM
    Bhanot, S
    Monia, BP
    DIABETES, 2005, 54 : A386 - A386
  • [37] Effects of puerarin in STZ-induced diabetic rats by oxidative stress and the TGF-β1/Smad2 pathway
    She, ShaoYi
    Liu, WeiJuan
    Li, Tong
    Hong, YingKai
    FOOD & FUNCTION, 2014, 5 (05) : 944 - 950
  • [38] SGLT2 inhibition ameliorates nano plastics-induced premature endothelial senescence and dysfunction
    Bikalpa Dhakal
    Saugat Shiwakoti
    Eun-Young Park
    Ki-Woon Kang
    Valérie B. Schini-Kerth
    Sun-Hwa Park
    Hye-Young Ji
    Joon Seok Park
    Ju-Young Ko
    Min-Ho Oak
    Scientific Reports, 13
  • [39] Protective Effect of Inhibition of Sglt2 on Nanoplastics-Induced Premature Endothelial Senescence and Dysfunction
    Dhakal, Bikalpa
    Shiwakoti, Saugat
    Ko, Ju-Young
    Kang, Ki-Woon
    Schini-Kerth, Valerie
    Oak, Min-Ho
    CIRCULATION, 2022, 146
  • [40] SGLT2 Inhibitor Dapagliflozin Alleviates Diabetic Nephropathy by Inhibiting High Glucose-induced Oxidative Stress in Diabetic Akita Mice
    Hatanaka, Takashi
    Ogawa, Daisuke
    Terami, Naoto
    Nishii, Naoko
    Nakatsuka, Atsuko
    Eguchi, Jun
    Wada, Jun
    DIABETES, 2015, 64 : A140 - A140