Macrolides: The Plug Is Out

被引：7
|
作者：
Gamerdinger, Martin [1 ]
Deuerling, Elke [1 ]
机构：
[1] Univ Konstanz, Dept Biol, D-78457 Constance, Germany
来源：
CELL | 2012年 / 151卷 / 03期
关键词：
LARGE RIBOSOMAL-SUBUNIT; ANTIBIOTICS;
D O I：
10.1016/j.cell.2012.10.015
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Macrolide antibiotics are thought to clog up the ribosomal tunnel and thereby block general protein synthesis. By using a combination of elegant in vivo and in vitro approaches, Kannan et al. show that the inhibitory action of these drugs on bacterial protein synthesis is selective rather than global.
引用
收藏
页码：469 / 471
页数：3
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