Macrolides: The Plug Is Out

被引：7
|
作者：
Gamerdinger, Martin [1 ]
Deuerling, Elke [1 ]
机构：
[1] Univ Konstanz, Dept Biol, D-78457 Constance, Germany
来源：
CELL | 2012年 / 151卷 / 03期
关键词：
LARGE RIBOSOMAL-SUBUNIT; ANTIBIOTICS;
D O I：
10.1016/j.cell.2012.10.015
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Macrolide antibiotics are thought to clog up the ribosomal tunnel and thereby block general protein synthesis. By using a combination of elegant in vivo and in vitro approaches, Kannan et al. show that the inhibitory action of these drugs on bacterial protein synthesis is selective rather than global.
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页码：469 / 471
页数：3
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