The role of the leukemia inhibitory factor receptor in neuroprotective signaling

被引：31
|
作者：
Davis, Stephanie M.
Pennypacker, Keith R. [1 ,2 ]
机构：
[1] Univ Kentucky, Dept Neurol, Ctr Adv Translat Stroke Sci, Bldg BBSRB,Off B457, Lexington, KY 40536 USA
[2] Univ Kentucky, Dept Neurosci, Ctr Adv Translat Stroke Sci, Bldg BBSRB,Off B457, Lexington, KY 40536 USA
来源：
PHARMACOLOGY & THERAPEUTICS | 2018年 / 183卷
关键词：
Cytokine; Signal transduction; Brain injury; Inflammation; CILIARY NEUROTROPHIC FACTOR; NEURAL STEM-CELLS; LIMITS AUTOIMMUNE DEMYELINATION; OLIGODENDROCYTE PRECURSOR CELLS; AMYOTROPHIC-LATERAL-SCLEROSIS; FIBROBLAST GROWTH FACTOR-2; ADULT CNS NEUROGENESIS; CENTRAL-NERVOUS-SYSTEM; ISCHEMIC BRAIN-INJURY; REGULATORY T-CELLS;
D O I：
10.1016/j.pharmthera.2017.08.008
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Several neurotropic cytokines relay their signaling through the leukemia inhibitory factor receptor. This 190 kDa subunit couples with the 130 kDa gp130 subunit to transduce intracellular signaling in neurons and oligoden-drocytes that leads to expression of genes associated with neurosurvival. Moreover, activation of this receptor alters the phenotype of immune cells to an anti-inflammatory one. Although cytokines that activate the leukemia inhibitory factor receptor have been studied in the context of neurodegenerative disease, therapeutic targeting of the specific receptor subunit has been understudied in by comparison. This review examines the role of this receptor in the CNS and immune system, and its application in the treatment in stroke and other brain pathologies.
引用
收藏
页码：50 / 57
页数：8
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